Publications by Wee Han Ang | EPFL Graph Search

Related publications (42)

An Internal Fluorescent Probe Based on Anthracene to Evaluate Cation-Anion Interactions in Imidazolium Salts

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Christian Hartinger, Wee Han Ang, Xuemei Yang

A series of fluorescent imidazolium-based salts contg. the cation [AnCH2MeIm]+ (in which An=anthracene and Im=the imidazolium cation) with Cl-, BF4-, PF6-, SO3CF3-, [N(CN)2]-, [N(SO2CF3)2]-, or PhBF3- anions have been prepd. and characterized. X-ray diffra ...

2010

Synthesis and characterizations of N,N-bis(diphenylphosphino)ethylaniline derivatives and X-ray crystal structure of palladium (II), platinum (II) complexes

Rosario Scopelliti, Zhaofu Fei, Wee Han Ang

N,N-Bis(diphenylphosphino)ethylaniline compounds, Ph2PN-C6H4-C2H5, with ethyl groups at the ortho- and para-positions have been synthesized. Oxidation of the aminophosphines with hydrogen peroxide, elemental sulfur and selenium gave the corresponding ...

2008

Mass spectrometric analysis of ubiquitin-platinum interactions of leading anticancer drugs: MALDI versus ESI

Paul Joseph Dyson, Christian Hartinger, Wee Han Ang, Angela Casini

The protein binding of anticancer metallodrugs is regarded as an important part in their mode of action both for delivering the active moiety into the tumor but also being responsible for deactivation and/or unwanted side effects. Characterization of prote ...

2007

Synthesis and characterization of platinum(IV) anticancer drugs with functionalized aromatic carboxylate ligands: Influence of the ligands on drug efficacies and uptake

Paul Joseph Dyson, Rosario Scopelliti, Wee Han Ang

A series of trans-platinum(IV) complexes with functionalized aromatic carboxylate ligands, cis,cis,trans-Pt(NH3)2Cl2(CO2C6H4R)2 (R = H (3), p-vinyl (4), p-methoxy (5), p-iodo (6), ...

2005

A Crystallographic Story of Snakes and Ladders: Encapsulated Water Polymers and Rigid Metal Complexes Based on Mono-N-substituted Carboxylate 4,4'-Bipyridine

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Wee Han Ang, Andrew Douglas Phillips

A new zwitterionic bidentate ligand was synthesized incorporating a 4,4'-bipyridine core with a carboxylate group as a single building block, specifically designed for the rational construction of supramol. structures (metal-org. frameworks) that are capab ...

2009

Phosphorylation of Diaminopyridines: Synthesis of a Compound Containing Both a Diphosphinoamine ( P-N-P) and an Iminobiphosphine ( N=P-P) Fragment

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Wee Han Ang, Emilia Paunescu

The phosphorylation of a series of diaminopyridines (2,3-, 3,4-, 2,5- and 2,6-diaminopyridine), with various molecular equivalents of chlorodiphenylphosphine in the presence of TEA has been studied. Notably, phosphorylation of 2,3- and 3,4-diaminopyridine ...

Wiley-V C H Verlag Gmbh2014

Acetal-Functionalized RAPTA Complexes for Conjugation and Labeling

Paul Joseph Dyson, Wee Han Ang

Ruthenium-arene complexes bearing the 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane ligand, namely, RAPTA compounds, are widely investigated as potential antimetastatic agents for cancer therapy. Although much evidence points toward covalent binding with ...

American Chemical Society2011

Characterization of New Potential Anticancer Drugs Designed To Overcome Glutathione Transferase Mediated Resistance

Paul Joseph Dyson, Wee Han Ang, Jie Zhang

Resistance against anticancer drugs remains a serious obstacle in cancer treatment. Here we used novel strategies to target microsomal glutathione transferase 1 (MGST1) and glutathione transferase pi (GSTP) that are often overexpressed in tumors and confer ...

2011

A strategy for the synthesis of transition-metal nanoparticles and their transfer between liquid phases

Paul Joseph Dyson, Zhaofu Fei, Wee Han Ang, Dongbin Zhao

Nanoparticles can be stabilized by an ionic liq. polymer (ILP) composed of imidazolium units incorporating a hydrophobic benzyl group. The resulting gold, platinum, and palladium nanoparticles can be efficiently transferred from water to ionic liqs. by exc ...

2006

Novel strategies for overcoming drug resistance in transition metal-based anticancer compounds

Wee Han Ang

Cisplatin is one of the most important and widely used anticancer drug in clinical use. However, its effectiveness is limited by its high toxicity and incidence of drug resistance. This has provided motivation for the search for transition metal-based drug ...

EPFL2007

Ionic solid-state dimers and polymers derived from imidazolium dicarboxylic acids

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Wee Han Ang

A series of imidazolium dicarboxylic acids have been prepd. from the reaction of the 1,3-bis(carboxymethyl)imidazolium zwitterion with the Bronsted acids HX (X = F, Br, Cl, ClO4). The structures of these acids have been established in the solid ...

2006

Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation

Paul Joseph Dyson, Ursula Röthlisberger, Wee Han Ang, Pablo Campomanes Ramos

Platinum-based cancer drugs, such as cisplatin, are highly effective chemotherapeutic agents used extensively for the treatment of solid tumors. However, their effectiveness is limited by drug resistance, which, in some cancers, has been associated with an ...

Wiley-Blackwell2011

Ruthenium Porphyrin Compounds for Photodynamic Therapy of Cancer

Paul Joseph Dyson, Wee Han Ang, Frédéric Schmitt

Five 5,10,15,20-tetra(4-pyridyl)porphyrin (TPP) areneruthenium(II) derivs., a p-cymeneosmium, a pentamethylcyclopentadienyliridium and a pentamethylcyclopentadienylrhodium analog were prepd. and characterized as potential photosensitizing chemotherapeutic ...

2008

Organometallic ruthenium inhibitors of glutathione-S-transferase P1-1 as anticancer drugs

Paul Joseph Dyson, Wee Han Ang

Ruthenium-arene complexes conjugated to ethacrynic acid were prepared as part of a strategy to develop novel glutathione-S-transferase (GST) inhibitors with alternate modes of activity through the organometallic fragment, ultimately to provide targeted rut ...

Wiley-Blackwell2007

Classical and Non-Classical Ruthenium-Based Anticancer Drugs: Towards Targeted Chemotherapy

Paul Joseph Dyson, Wee Han Ang

Ruthenium-based anticancer chemotherapies are making significant advances in clinical trials. Until recently, the focus has been on coordination complexes, and mechanisms such as "activation by reduction" and "transferrin-targeted delivery" have been propo ...

2006

Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis

Paul Joseph Dyson, Wee Han Ang

The present invention relates to organometallic compounds useful in the treatment of metastasis. The organometallic compounds comprise a ligand that is convalently bound to a bioactive compound, which is an inhibitor of a resistance pathway or a derivative ...

2007

Ferrocenoyl Pyridine Arene Ruthenium Complexes with Anticancer Properties: Synthesis, Structure, Electrochemistry, and Cytotoxicity

Paul Joseph Dyson, Wee Han Ang

Reaction of the dimers [Ru(h6-arene)Cl2]2 (arene = C6H6, C6H5Me, p-iPrC6H4Me, C6Me6) with 2 equiv of the ferrocenoyl pyridine (NC5H4(OOCC5H4FeC5H5)-4) affords Ru(II) complexes [Ru(h6-arene)Cl2(NC5H4OOCC5H4FeC5H5)] (arene = C6H6 (1, 85% yield), C6H5Me (2, 8 ...

2008

Development of Ruthenium Antitumor Drugs that Overcome Multidrug Resistance Mechanisms

Paul Joseph Dyson, Rosario Scopelliti, Wee Han Ang, Andrew Douglas Phillips, Claudine Scolaro

Organometallic ruthenium(II) complexes of the general formula [Ru(η6-p-cymene)Cl2(L)] and [Ru(η6-p-cymene)Cl(L)2][BPh4] with modified phenoxazine- and anthracene-based multidrug resistanc ...

2007

Aminophosphine complex as a catalyst precursor in Suzuki coupling reactions

Zhaofu Fei, Wee Han Ang, Dongbin Zhao

A palladium complex with an aminophosphine ligand has been prepared and investigated as a catalyst precursor in Suzuki coupling reactions in toluene. Nanoparticles composed of elemental palladium have been isolated from the reaction media and analyzed usin ...

2008

Organometallic complexes that interconvert between trimeric and monomeric structures as a function of pH and their effect on human cancer and fibroblast cells

Paul Joseph Dyson, Rosario Scopelliti, Kay Severin, Wee Han Ang, Zacharias Immanuel Grote

Organometallic half-sandwich complexes based on ruthenium with aminomethyl-substituted 3-hydroxy-2-pyridone ligands exist in aqueous solution as monomeric O,O′-chelate complexes or trimeric metallamacrocycles depending upon the pH. We hypothesized that adm ...

2009