Publications by Carl Petersen | EPFL Graph Search

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Sensory processing, sensorimotor integration and motor control are amongst the most basic functions of the brain and yet our understanding of how the underlying neuronal networks operate and contribute to behaviour is very limited. The relative simplicity ...

Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in ...

Avermann M, Tomm C, Mateo C, Gerstner W, Petersen CC. Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex. J Neurophysiol 107: 3116-3134, 2012. First published March 7, 2012; doi:10.1152/jn.00917.2011.-Synaptic interactio ...

The array of whiskers on the snout provides rodents with tactile sensory information relating to the size, shape and texture of objects in their immediate environment. Rodents can use their whiskers to detect stimuli, distinguish textures, locate objects a ...

Cortical motor maps represent fundamental organizing principles for voluntary motor control,1 yet their underlying structure remains poorly understood, including regions of sensory2,3 and parietal cortex,4 as well as the classical frontal motor cortex. To ...

Precisely wired neuronal circuits process sensory information in a learning- and context-dependent manner in order to govern behavior. Simple sensory decision-making tasks in rodents are now beginning to reveal the contributions of distinct cell types and ...

Sensorimotor processing occurs in a highly distributed manner in the mammalian neocortex. The spatiotemporal dynamics of electrical activity in the dorsal mouse neocortex can be imaged using voltage-sensitive dyes (VSDs) with near-millisecond temporal reso ...

The primary somatosensory barrel cortex processes tactile vibrissae information, allowing rodents to actively perceive spatial and textural features of their immediate surroundings. Each whisker on the snout is individually represented in the neocortex by ...

Communication between cortical areas contributes importantly to sensory perception and cognition. On the millisecond time scale, information is signaled from one brain area to another by action potentials propagating across long-range axonal arborizations. ...

Neuronal response properties are typically probed by intracellular measurements of current-voltage (I-V) relationships during application of current or voltage steps. Here we demonstrate the measurement of a novel I-V curve measured while the neuron exhibi ...

Sensory information is processed in distributed neuronal networks connected by intricate synaptic circuits. Studies of the rodent brain can provide insight into synaptic mechanisms of sensory perception and associative learning. In particular, the mouse wh ...

Uniform random sparse network architectures are ubiquitous in computational neuroscience, but the implicit hypothesis that they are a good representation of real neuronal networks has been met with skepticism. Here we used two experimental data sets, a stu ...

Viral vectors injected into the mouse brain offer the possibility for localized genetic modifications in a highly controlled manner. Lentivector injection into mouse neocortex transduces cells within a diameter of approximately 200mum, which closely matche ...

Internal brain states form key determinants for sensory perception, sensorimotor coordination and learning. A prominent reflection of different brain states in the mammalian central nervous system is the presence of distinct patterns of cortical synchrony, ...

Goal-directed behaviors involve coordinated activity in many cortical areas, but whether the encoding of task variables is distributed across areas or is more specifically represented in distinct areas remains unclear. Here, we compared representations of ...

Background: Synaptic interactions between excitatory and inhibitory neocortical neurons are important for mammalian sensory perception. Synaptic transmission between identified neurons within neocortical microcircuits has mainly been studied in brain slice ...

Mice can gather tactile sensory information by actively moving their whiskers to palpate objects in their immediate surroundings. Whisker sensory perception therefore requires integration of sensory and motor information, which occurs prominently in the ne ...

Voltage-sensitive dye imaging resolves the spatiotemporal dynamics of supragranular subthreshold cortical activity with millisecond temporal resolution and subcolumnar spatial resolution. We used a flexible fiber optic image bundle to visualize voltage-sen ...

Behavioral states can influence performance of goal-directed sensorimotor tasks. Yet, it is unclear how altered neuronal sensory representations in these states relate to task performance and learning. We trained water-restricted mice in a two-whisker disc ...

Neocortical neurons can increasingly be divided into well-defined classes, but their activity patterns during quantified behavior remain to be fully determined. Here, we obtained membrane potential recordings from various classes of excitatory and inhibito ...

Carl Petersen

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Genetic manipulation, whole-cell recordings and functional imaging of the sensorimotor cortex of behaving mice

Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex

Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex

Neuronal Circuits In Barrel Cortex For Whisker Sensory Perception

Cell-class-specific orofacial motor maps in mouse neocortex

Neural Circuits for Goal-Directed Sensorimotor Transformations

Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task

Long-range connectivity of mouse primary somatosensory barrel cortex

Axonal and Dendritic Morphology of Excitatory Neurons in Layer 2/3 Mouse Barrel Cortex Imaged Through Whole-Brain Two-Photon Tomography and Registered to a Digital Brain Atlas

Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces

Layer, column and cell-type specific genetic manipulation in mouse barrel cortex

Connection-type-specific biases make uniform random network models consistent with cortical recordings

Layer- and column-specific knockout of NMDA receptors in pyramidal neurons of the mouse barrel cortex

Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice

Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior

In Vivo Optogenetic Stimulation of Neocortical Excitatory Neurons Drives Brain-State-Dependent Inhibition

Parallel pathways from motor and somatosensory cortex for controlling whisker movements in mice

Visualizing the cortical representation of whisker touch: voltage-sensitive dye imaging in freely moving mice

Cortical sensory processing across motivational states during goal-directed behavior

Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing