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Jörg Grandl

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Related publications (5)

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Structure and function of the nicotinic acetylcholine receptor

Jörg Grandl

The subject of this thesis is the study of the structure and function of the human muscle nicotinic acetylcholine receptor (nAChR), which is a typical member of the large class of ligand-gated ion channels. Appropriate techniques, like site-directed mutage ...

EPFL2005

Modulation of proton-induced current fluctuations in the human nicotinic acetylcholine receptor channel

Horst Arthur Vogel, Rudolf Hovius, Christophe Danelon, Jörg Grandl

The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that switches upon activation from a closed state to a full conducting state. We found that the mutation delta S268K, located at 12' position of the second transmembrane domain of t ...

2007

New conjugate of agonist ligand directed to ligand-gated ion channels of cysteine loop-family with chromophore, useful, e.g. in receptor proteins/their interaction with agonistic ligand and to study the effect of unlabelled ligands

Horst Arthur Vogel, Rudolf Hovius, Jörg Grandl

NOVELTY - Conjugate (I) of an agonist ligand directed to ligand-gated ion channels (LGICs) of the Cys loop-family with a chromophore, is new. USE - (I) is useful in the receptor proteins and/or their interaction with the agonistic ligand, where the interac ...

2007

Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors

Horst Arthur Vogel, Rudolf Hovius, Christophe Danelon, Jörg Grandl

Nicotinic acetylcholine receptors are heteropentameric ion channels that open upon activation to a single conducting state. The second transmembrane segments of each subunit were identified as channel-forming elements, but their respective contribution in ...

Springer-Verlag2006

Fluorescent Epibatidine Agonists for Neuronal and Muscle-Type Nicotinic Acetylcholine Receptors

Horst Arthur Vogel, Rudolf Hovius, Jörg Grandl

Wiley-VCH Verlag GmbH2007