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Henry Markram

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Related publications (167)

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A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Henry Markram, Werner Alfons Hilda Van Geit, Tanguy Pierre Louis Damart, Darshan Mandge, Aurélien Tristan Jaquier, Mickael Maurice Zbili

In computational neuroscience, multicompartment models are among the most biophysically realistic representations of single neurons. Constructing such models usually involves the use of the patch-clamp technique to record somatic voltage signals under diff ...

2024

Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain circuits

Henry Markram, Michele Giugliano

The unique properties of single-wall carbon nanotubes (SWNTs) and the application of nanotechnology to the nervous system may have a tremendous impact in the future developments of microsystems for neural prosthetics as well as immediate benefits for basic ...

2007

Cell Densities in the Mouse Brain: A Systematic Review

Henry Markram, Daniel Keller, Csaba Erö

The mouse brain is the most extensively studied brain of all species. We performed an exhaustive review of the literature to establish our current state of knowledge on cell numbers in mouse brain regions, arguably the most fundamental property to measure ...

2018

Effective Stimuli for Constructing Reliable Neuron Models

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

The rich dynamical nature of neurons poses major conceptual and technical challenges for unraveling their nonlinear membrane properties. Traditionally, various current waveforms have been injected at the soma to probe neuron dynamics, but the rationale for ...

2011

BlueCelluLab: Biologically Detailed Neural Network Experimentation API

Henry Markram, Eilif Benjamin Muller, Werner Alfons Hilda Van Geit, Lida Kanari, Mustafa Anil Tuncel, Darshan Mandge, Aurélien Tristan Jaquier

The NEURON simulator, established in 1984 and continuously developed since, stands as the preeminent tool for neuron simulation within computational neuroscience. Its widespread adoption and compatibility with computational clusters and supercomputers unde ...

The Open Journal2024

Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid

Henry Markram, Tania Rinaldi, Karina Kulangara

Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis. Learning and memory alterations are common symptoms of ASD, but underlyin ...

National Academy of Sciences2007

From Neuron Biophysics to Orientation Selectivity in Electrically Coupled Networks of Neocortical L2/3 Large Basket Cells

Henry Markram, Eilif Benjamin Muller, Idan Segev, Werner Alfons Hilda Van Geit

In the neocortex, inhibitory interneurons of the same subtype are electrically coupled with each other via dendritic gap junctions (GJs). The impact of multiple GJs on the biophysical properties of interneurons and thus on their input processing is unclear ...

Oxford University Press (OUP)2016

Interactive visualization and analysis of morphological skeletons of brain vasculature networks with VessMorphoVis

Snigdha Dagar, Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jean-Denis Georges Emile Courcol, Jay Coggan, Nadir Roman Guerrero, Benoît Jean-Albert Coste, Samuel Lieven D. Lapere

Motivation: Accurate morphological models of brain vasculature are key to modeling and simulating cerebral blood flow in realistic vascular networks. This in silico approach is fundamental to revealing the principles of neurovascular coupling. Validating t ...

Oxford University Press2020

Cell-type-specific densities in mouse somatosensory cortex derived from scRNA-seq and in situ RNA hybridization

Henry Markram, Daniel Keller, Csaba Verasztó

Cells in the mammalian cerebral cortex exhibit layer-dependent patterns in their distribution. Classical methods of determining cell type distributions typically employ a painstaking process of large-scale sampling and characterization of cellular composit ...

FRONTIERS MEDIA SA2023

Substrate arrays of iridium oxide microelectrodes for in-vitro neuronal interfacing

Philippe Renaud, Henry Markram, Michele Giugliano, Marc Olivier Heuschkel, Shady Didier Gawad

The design of novel bidirectional interfaces for in vivo and in vitro nervous systems is an important step towards future functional neuroprosthetics. Small electrodes, structures and devices are necessary to achieve high-resolution and target-selectivity ...

2009

Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex

Henry Markram, Eilif Benjamin Muller, Rodrigo de Campos Perin, Srikanth Ramaswamy, Giuseppe Chindemi, Natali Barros Zulaica

Previous studies based on the 'Quantal Model' for synaptic transmission suggest that neurotransmitter release is mediated by a single release site at individual synaptic contacts in the neocortex. However, recent studies seem to contradict this hypothesis ...

2019

The Role of Hub Neurons in Modulating Cortical Dynamics

Henry Markram, Felix Schürmann, Idan Segev

Many neurodegenerative diseases are associated with the death of specific neuron types in particular brain regions. What makes the death of specific neuron types particularly harmful for the integrity and dynamics of the respective network is not well unde ...

2021

A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data

Henry Markram, Idan Segev

We present a novel framework for automatically constraining parameters of compartmental models of neurons, given a large set of experimentally-measured responses of these neurons. In experiments, intrinsic noise gives rise to a large variability (e.g., in ...

2007

Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons

Henry Markram

We review here the development of Hodgkin-Huxley (HH) type models of cerebral cortex and thalamic neurons for network simulations. The intrinsic electrophysiological properties of cortical neurons were analyzed from several preparations, and we selected th ...

2008

Data-Driven Modeling of Cholinergic Modulation of Neural Microcircuits: Bridging Neurons, Synapses and Network Activity

Henry Markram, Srikanth Ramaswamy, Cristina Colangelo

Neuromodulators, such as acetylcholine (ACh), control information processing in neural microcircuits by regulating neuronal and synaptic physiology. Computational models and simulations enable predictions on the potential role of ACh in reconfiguring netwo ...

2018

Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments

Henry Markram, Michele Giugliano, Elena Katsyuba

Although previous studies of Huntington's disease (HD) have addressed many potential mechanisms of striatal neuron dysfunction and death, it is also known, based on clinical findings, that cortical function is dramatically disrupted in HD. With respect to ...

American Society for Pharmacology and Experimental Therapeutics2010

Cell density quantification of high resolution Nissl images of the juvenile rat brain

Csaba Zsolnai, Henry Markram, Daniel Keller, Olivier Burri, Rodrigo de Campos Perin, Ying Shi, Julie Meystre, João Luís Prado Vieira, Jean Nicolas Jacquemier

Copyright © 2024 Meystre, Jacquemier, Burri, Zsolnai, Frank, Vieira, Shi, Perin, Keller and Markram.Nissl histology underpins our understanding of brain anatomy and architecture. Despite its importance, no high-resolution datasets are currently available i ...

2024

Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors

Henry Markram

Astrocytes can both sense and shape the evolution of neuronal network activity and are known to possess unique ion regulatory mechanisms. Here we explore the relationship between astrocytic intracellular pH dynamics and the synchronous network activity tha ...

Soc Neuroscience2016

Cell-type- and activity-dependent extracellular correlates of intracellular spiking

Constantinos Anastassiou, Henry Markram, Rodrigo de Campos Perin

Despite decades of extracellular action potential (EAP) recordings monitoring brain activity, the biophysical origin and inherent variability of these signals remains enigmatic. We performed whole-cell patch recordings of excitatory and inhibitory neurons ...

2015

Ephaptic coupling of cortical neurons

Henry Markram, Rodrigo de Campos Perin, Constantinos Anastassiou

The electrochemical processes that underlie neural function manifest themselves in ceaseless spatiotemporal field fluctuations. However, extracellular fields feed back onto the electric potential across the neuronal membrane via ephaptic coupling, independ ...

2011