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Jean-Charles Bensadoun

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Related publications (25)

Page 1 of 2

Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF

Patrick Aebischer, Nicole Déglon, Jean-Charles Bensadoun

Local delivery of therapeutic molecules represents one of the limiting factors for the treatment of neurodegenerative disorders. In vivo gene transfer using viral vectors constitutes a powerful strategy to overcome this limitation. The aim of the present s ...

2000

Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease

Patrick Aebischer, Nicole Déglon, Jean-Charles Bensadoun

Reactive oxygen species are considered to contribute to the pathogenesis of Parkinson's disease (PD). In order to study viral vector-mediated overexpression of the antioxidant enzyme glutathione peroxidase (GPX) as a potential neuroprotective approach in b ...

2006

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

Patrick Aebischer, Didier Trono, Jean-Charles Bensadoun, Romain Zufferey

Glial cell line-derived neurotrophic factor (GDNF) is able to protect dopaminergic neurons against various insults and constitutes therefore a promising candidate for the treatment of Parkinson's disease. Lentiviral vectors that infect quiescent neuronal c ...

2000

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS

Patrick Aebischer, Jean-Charles Bensadoun, Sandrine Guillot

Mutations in Cu/Zn superoxide dismutase (encoded by SOD1), one of the causes of familial amyotrophic lateral sclerosis (ALS), lead to progressive death of motoneurons through a gain-of-function mechanism. RNA interference (RNAi) mediated by viral vectors a ...

2005

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

Patrick Aebischer, Nicole Déglon, Jean-Charles Bensadoun, Diana Zala

Ciliary neurotrophic factor (CNTF) has been shown to prevent behavioral deficits and striatal degeneration in neurotoxic models of Huntington's disease (HD), but its effect in a genetic model has not been evaluated. Lentiviral vectors expressing the human ...

2004

Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice

Patrick Aebischer, Jean-Charles Bensadoun

Normal cellular metabolism produces oxidants which are neutralized within cells by antioxidant enzymes and other antioxidants. An imbalance between oxidants and antioxidants has been postulated to lead to the degeneration of specific populations of neurons ...

1998

Imaging brain amyloid deposition using grating-based differential phase contrast tomography

Patrick Aebischer, Jean-Charles Bensadoun, Peter Modregger

One of the core pathological features of Alzheimer's disease (AD) is the accumulation of amyloid plaques in the brain. Current efforts of medical imaging research aim at visualizing amyloid plaques in living patients in order to evaluate the progression of ...

Elsevier2012

Viral vectors as a tool to model and treat Parkinson's disease

Patrick Aebischer, Jean-Charles Bensadoun

2006

Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

Patrick Aebischer, Marco Cantoni, Graham Knott, Ralf Schneggenburger, Jean-Charles Bensadoun, Wojciech Janusz Bobela, Özgür Genç

alpha-Synuclein (alpha-syn) is a presynaptic protein present at most nerve terminals, but its function remains largely unknown. The familial forms of Parkinson's disease associated with multiplications of the alpha-syn gene locus indicate that overabundanc ...

Springer-Verlag2012

Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons

Bernard Schneider, Jean-Charles Bensadoun

Several diseases and injuries of the central nervous system could potentially be treated by delivery of an enzyme, which might most effectively be achieved by gene therapy. In particular, the bacterial enzyme chondroitinase ABC is beneficial in animal mode ...

Elsevier2011

KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress

Maria del Carmen Sandi Perez, Didier Trono, Maria Isabel Cordero Campana, Jean-Charles Bensadoun, Anna Claire Groner

KAP1 is an essential cofactor of KRAB-zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. Here, we report that KAP1 is expressed at high levels and ...

2008

Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease

Patrick Aebischer, Bernard Schneider, Jean-Charles Bensadoun, Christophe Lo Bianco

Numerous studies have shown the neuroprotective and regenerative benefits of glial cell line-derived neurotrophic factor (GDNF) in animal models of PD. Brain delivery of GDNF can, however, be associated with limiting side-effects in both primates and PD pa ...

2006

Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease

Patrick Aebischer, Bernard Schneider, Jean-Charles Bensadoun, Julien Dusonchet

Loss of function of parkin, an ubiquitin ligase, is responsible for autosomal recessive juvenile parkinsonism (AR-JP). Parkin-associated endothelin receptor-like receptor (Pael-R) was identified as an authentic substrate of parkin and is thought to accumul ...

2009

Controlled Release Drug Coatings on Flexible Neural Probes

Jeffrey Alan Hubbell, Philippe Renaud, Arnaud Bertsch, Jean-Charles Bensadoun, André Mercanzini, Philippe André Guy Colin

We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biod ...

2007

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

Rolf Gruetter, Maria del Carmen Sandi Perez, Patrick Aebischer, Maurizio Molinari, Maria Isabel Cordero Campana, Jean-Charles Bensadoun, Nicolas Bouche, Veronica Setola

BACKGROUND: Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current pri ...

Public Library of Science2011

Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor

Patrick Aebischer, Jean-Charles Bensadoun

We investigated whether a continuous supply of glial cell line-derived neurotrophic factor (GDNF) via encapsulated genetically modified cells can promote survival and fiber outgrowth from xenotransplanted human dopaminergic neurons. Cells genetically engin ...

2005

Demonstration of cortical recording using novel flexible polymer neural probes

Philippe Renaud, Arnaud Bertsch, Jean-Charles Bensadoun, André Mercanzini, Philippe André Guy Colin, Karen Cheung, Marc Jasper Boers

We present the fabrication, characterization, use in cortical recording and histological results of a flexible implantable neural probe. The microfabricated device is implemented in polyimide and platinum providing mechanical flexibility, high quality elec ...

2008

Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

Patrick Aebischer, Nicole Déglon, Jean-Charles Bensadoun, Eric Garrison Fine

Glial cell line-derived neurotrophic factor (GDNF) holds great promise for the treatment of Parkinson's disease. In humans, its intracerebroventricular administration leads to limiting side effects. Direct parenchymal delivery using mechanical means, or ce ...

2003

Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

Patrick Aebischer, Nicole Déglon, Jean-Charles Bensadoun

Ciliary neurotrophic factor prevents behavioural deficits and striatal degeneration in rat and primate models of Huntington's disease. Interleukin- 6, another member of the cytokine family, and the chimeric molecule (IL6/IL6R) in which interleukin-6 and it ...

2001

Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model

Patrick Aebischer, Jean-Charles Bensadoun

X-linked adrenoleukodystrophy (X-ALD) is the most common inherited peroxisomal disorder characterized by a progressive demyelination of the central nervous system. The marked loss of myelin and oligodendrocytes observed in the disease prompted us to evalua ...

2009