Publications by André Mercanzini

Related publications (15)

The tissue reaction to neuroprostheses

Neuroprostheses were developed for a variety of applications using unique microfabrication methods. A technology platform that enables novel microelectrode array designs and microfluidic channels is described. Experiments demonstrating the in vivo utility ...

EPFL2009

Implantable probe for stimulating neurological target e.g. neurons and subthalamic nucleus, has several microelectrode elements arranged at distal end of elongated probe shaft, and electrical contact arranged proximally along shaft

Philippe Renaud, André Mercanzini

Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged alon ...

2010

Directional Local Field Potentials in the Subthalamic Nucleus During Deep Brain Implantation of Parkinson's Disease Patients

André Mercanzini

Segmented deep brain stimulation leads feature directional electrodes that allow for a finer spatial control of electrical stimulation compared to traditional ring-shaped electrodes. These segmented leads have demonstrated enlarged therapeutic windows and ...

2020

Implantable neurological probe for performing physiological measurement of patient, has microelectrode element that is arranged along the protrusion extended away from surface of supportive backing layer

Philippe Renaud, André Mercanzini

Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged alon ...

2011

Controlled Release Drug Coatings on Flexible Neural Probes

Jeffrey Alan Hubbell, Philippe Renaud, Arnaud Bertsch, Jean-Charles Bensadoun, André Mercanzini, Philippe André Guy Colin

We present the development, characterization and in vivo validation of a novel drug eluting coating that has been applied to flexible neural probes. The coating consists of drug eluting nanoparticles loaded with an anti-inflammatory drug embedded in a biod ...

2007

Demonstration of cortical recording using novel flexible polymer neural probes

Philippe Renaud, Arnaud Bertsch, Jean-Charles Bensadoun, André Mercanzini, Philippe André Guy Colin, Karen Cheung, Marc Jasper Boers

We present the fabrication, characterization, use in cortical recording and histological results of a flexible implantable neural probe. The microfabricated device is implemented in polyimide and platinum providing mechanical flexibility, high quality elec ...

2008

Implantable neurological probe for identifying location of neurological target e.g. neurons, has stylet provided in internal lumen and configured to contact support cylinder to selectively extend shafts during implantation

Philippe Renaud, André Mercanzini

The probe has support cylinder (214) that is slidingly provided in distal portion of internal lumen. Several shafts coupled to support cylinder and arranged to be selectively extended from distal end of elongated shaft. Several conductive traces provided o ...

2011

Integration of 2D and 3D Thin Film Glassy Carbon Electrode Arrays for Electrochemical Dopamine Sensing in Flexible Neuroelectronic Implants

Philippe Renaud, André Mercanzini, Jules John Vandersarl

Here we present the development and characterization of a flexible implantable neural probe with glassy carbon electrode arrays. The use of carbon electrodes allows for these devices to be used as chemical sensors, in addition to their typical use as elect ...

Wiley-Blackwell2015

Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus

Philippe Renaud, André Mercanzini

Objective Segmented deep brain stimulation leads in the subthalamic nucleus have shown to increase therapeutic window using directional stimulation. However, it is not fully understood how these segmented leads with reduced electrode size modify the volume ...

PUBLIC LIBRARY SCIENCE2019

Technology developments to initiate a next generation of Cochlear Implants

Arnaud Bertsch, André Mercanzini

In the framework of the EU-supported research project Healthy Aims, we developed a range of novel electrode arrays and related technologies for use in hearing prosthesis. This paper summarizes our ongoing research activities on alternative electrode manufa ...

IEEE2007

Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses

Philippe Renaud, Jeffrey Alan Hubbell, Jean-Charles Bensadoun, André Mercanzini, Philippe André Guy Colin

Controlled release coatings were developed for neuroprostheses with the aim of combating the tissue reaction following implantation in the brain. The coatings consist of poly(propylene sulfide) drug-eluting nanoparticles embedded in a poly(ethylene oxide) ...

Elsevier2010

Stimulating apparatus for stimulating neurological target of live animal has stimulation source in communication with at least one micro-electrode to stimulate neurological target at respective preferred frequency

Philippe Renaud, André Mercanzini

A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is prov ...

2010

in vivo Electrical Impedance Spectroscopy of Tissue Reaction to Microelectrode Arrays

Philippe Renaud, Arnaud Bertsch, Jean-Charles Bensadoun, André Mercanzini, Philippe André Guy Colin

The goal of this experiment was to determine the electrical properties of the tissue reaction to implanted microelectrode arrays. We describe a new method of analyzing electrical impedance spectroscopy data to determine the complex impedance of the tissue ...

2009

Demonstration of cortical recording and reduced inflammatory response using flexible polymer neural probes

Philippe Renaud, Arnaud Bertsch, Jean-Charles Bensadoun, André Mercanzini, Philippe André Guy Colin, Karen Cheung, Marc Jasper Boers

2007

The effect of biodegradable drug release coatings on the electrical characteristrics of neural electrodes

Jeffrey Alan Hubbell, Philippe Renaud, Arnaud Bertsch, André Mercanzini, Marc Jasper Boers

2007