Jeffrey Alan Hubbell

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While cell sorting usually relies on cell-surface protein markers, molecular beacons (MBs) offer the potential to sort cells based on the presence of any expressed mRNA and in principle could be extremely useful to sort rare cell populations from primary i ...

The present invention features linear and three-dimensional supramolecular materials self-assembled from block copolymers comprising oligo(ethylene sulfide) (OES). The block copolymers assemble into fibrils, micelles, or matrices. The fibrillar materials a ...

Heparin binding peptides derived from a Tenascin (TNC) III1-5 domain or a fibrinogen ²15-66 domain have been found that bind certain cytokines with high affinity. Materials and methods for making compositions and devices using these peptides are disclosed. ...

We present a microfluidic device where micro- and nanoparticles can be continuously functionalized in flow. This device relies on an element called particle exchanger, which allows for particles to be taken from one medium and exposed to some reagent while ...

Delivery of biodegradable nanoparticles to antigen-presenting cells (APCs), specifically dendritic cells (DCs), has potential for immunotherapy. This study investigates the delivery of 20, 45, and 100nm diameter poly(ethylene glycol)-stabilized poly(propyl ...

Cationic micelles formed from poly(ethylene glycol)-bl-poly(propylene sulfide)-bl-poly(ethylene imine) (PEG-b-PPS-b-PEI) and from mixtures of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-b-PPS) with PEG-b-PPS-b-PEI were explored as non-viral vecto ...

Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared a ...

The invention relates to a scaffold material comprising a carrier and embedded microbeads for use in tissue engineering applications such as soft tissues therapeutic treatment. The scaffold provides a short-term bulking effect coupled with a long-term func ...

Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and im ...

Jeffrey Alan Hubbell

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Sorting Live Stem Cells Based on Sox2 mRNA Expression

Hepatocyte-dependent cross-presentation of soluble antigens induces antigen-specific CD8(+) T cell tolerance

High aspect ratio nanofibril materials

Extracellular matrix heparin-binding domains

Dielectrophoresis-based particle exchanger for the manipulation and surface functionalization of particles

In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles

Therapeutic Angiogenesis by Short-Term Co-Delivery of Fibrin-Bound VEGF and PDGF-BB Proteins

PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: Tumor immunotoxicity in B16F10 melanoma

Growth factors engineered for super-affinity to extracellular matrix enhance tissue healing

Injectable biomimetic matrices to guide impaired wound healing

Short-Term Delivery of Fibrin-Bound VEGF Protein in Osteogenic Grafts ensures both Increased Vascularization and Efficient Bone Formation

Erythrocyte-binding therapeutics

Fibrin delivery systems for elastic tissue regeneration

Extracellular matrix molecules regulate growth factor and cytokine delivery through their heparin-binding domains and promote wound healing

Synthetic fibrin-like matrix for bone tissue engineering

Tissue Engineered Collagen Based Tubular Scaffolds for Urethral Regeneration. A Novel Technology for the Surgical Treatment of VSD (Variation of Sex Development) Patients with Severe Hypospadias

Natural polymer-derived scaffold material and methods for production thereof

Normalization and Accelerated Stabilization of VEGF-Induced Angiogenesis by Co-Delivery of Engineered PDGF-BB and VEGF Proteins From Fibrin Matrices

Glycotargeting therapeutics

Exploiting lymphatic transport and complement activation in nanoparticle vaccines