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Bruno Meyer

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Related publications (5)

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Investigation of the neurokinin-1 receptor by fluorescence techniques

Bruno Meyer

G protein-coupled receptors (GPCR) constitute by far the largest family of transmembrane cell-surface proteins involved in signal transduction and are the most important targets for the development of novel therapeutic compounds. Many processes mediated by ...

EPFL2005

Kinetics of the initial steps of G protein-coupled receptor-mediated cellular signaling revealed by single-molecule imaging

Horst Arthur Vogel, Bruno Meyer

We report on an in vivo single-mol. study of the signaling kinetics of G protein-coupled receptors (GPCR) performed using the neurokinin 1 receptor (NK1R) as a representative member. The NK1R signaling cascade is triggered by the specific binding of a fluo ...

2005

CD8+ Cytotoxic T Lymphocyte Activation by Soluble Major Histocompatibility Complex-Peptide Dimers

Horst Arthur Vogel, Jean-Manuel Segura, Bruno Meyer

CD8+ cytotoxic T lymphocyte (CTL) can recognize and kill target cells that express only a few cognate major histocompatibility complex class I-peptide (pMHC) complexes. To better understand the mol. basis of this sensitive recognition process, the authors ...

2005

Covalent labeling of cell-surface proteins for in-vivo FRET studies

Horst Arthur Vogel, Kai Johnsson, Rudolf Hovius, Jean-Manuel Segura, Nathalie George, Bruno Meyer

Fluorescence resonance energy transfer (FRET) is a powerful technique to reveal interactions between membrane proteins in live cells. Fluorescence labeling for FRET is typically performed by fusion with fluorescent proteins (FP) with the drawbacks of a lim ...

2006

Posttranslational covalent labeling reveals heterogeneous mobility of individual G protein-coupled receptors in living cells

Horst Arthur Vogel, Kai Johnsson, Jean-Manuel Segura, Nathalie George, Bruno Meyer

2006