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Pierre Magistretti

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Related publications (180)

Glycogen: a Trojan horse for neurons

Pierre Magistretti, Igor Allaman

2007

A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism

Pierre Magistretti, Luc Pellerin

Functional neuroimaging has undergone spectacular developments in recent years. Paradoxically, its neurobiological bases have remained elusive, resulting in an intense debate around the cellular mechanisms taking place upon activation that could contribute ...

National Academy of Sciences2007

Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase

Pierre Magistretti, Jonathan Thevenet, Cristina Granziera

We have studied ischemic tolerance induced by the serine protease thrombin in two different models of experimental ischemia. In organotypic hippocampal slice cultures, we demonstrate that incubation with low doses of thrombin protects neurons against a sub ...

2007

TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity

Pierre Magistretti, Jean-René Cardinaux, Kim Do

A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term mem ...

National Academy of Sciences2007

Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase

Pierre Magistretti, Luc Pellerin

BACKGROUND: For a long time now, glucose has been thought to be the main, if not the sole substrate for brain energy metabolism. Recent data nevertheless suggest that other molecules, such as monocarboxylates (lactate and pyruvate mainly) could be suitable ...

2007

Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex

Pierre Magistretti, Stephanie Clarke, Luc Pellerin

Distribution of the monocarboxylate transporter MCT1 has been investigated in the cortex of normal adult human brain. Similarly to the glucose transporter GLUT1 55 kDa isoform, MCT1 was found to be strongly expressed on blood vessels in all cortical layers ...

2006

C/EBPbeta couples dopamine signalling to substance P precursor gene expression in striatal neurones

Pierre Magistretti, Jean-René Cardinaux

Dopamine-induced changes in striatal gene expression are thought to play an important role in drug addiction and compulsive behaviour. In this study we report that dopamine induces the expression of the transcription factor CCAAT/Enhancer Binding Protein b ...

Wiley-Blackwell2006

Glucose and lactate are equally effective in energizing activity-dependent synaptic vesicle turnover in purified cortical neurons

Pierre Magistretti, Jean-Yves Chatton

This study examines the role of glucose and lactate as energy substrates to sustain synaptic vesicle cycling. Synaptic vesicle turnover was assessed in a quantitative manner by fluorescence microscopy in primary cultures of mouse cortical neurons. An elect ...

Elsevier2006

Neuron-glia metabolic coupling and plasticity

Pierre Magistretti

The coupling between synaptic activity and glucose utilization (neurometabolic coupling) is a central physiological principle of brain function that has provided the basis for 2-deoxyglucose-based functional imaging with positron emission tomography (PET). ...

2006

Measurement of the integral refractive index and dynamic cell morphometry of living cells with digital holographic microscopy

Etienne Cuche, Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Benjamin Rappaz

We have developed a digital holographic microscope (DHM), in a transmission mode, adapted to the quantitative study of cellular dynamics. Living cells in culture are optically probed by measuring the phase shift they produce on the transmitted wave front. ...

2005

Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy

Tristan Colomb, Etienne Cuche, Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Benjamin Rappaz

We have developed a digital holographic microscope (DHM), in a transmission mode, especially dedicated to the quantitative visualization of phase objects such as living cells. The method is based on an original numerical algorithm presented in detail elsew ...

2005

Digital holographic microscopy for study cellular dynamics

Etienne Cuche, Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Benjamin Rappaz

Based on an original numerical reconstruction algorithm (E. Cuche et al. Appl. Opt. 38, 6994 1999), we have developed a Digital Holographic Microscope (DHM), in a transmission mode, allowing to investigate noninvasively cellular structures and dynamics. DH ...

SPIE2005

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation

Pierre Magistretti, Luc Pellerin

A critical issue in brain energy metabolism is whether lactate produced within the brain by astrocytes is taken up and metabolized by neurons upon activation. Although there is ample evidence that neurons can efficiently use lactate as an energy substrate, ...

National Academy of Sciences2005

Digital Holographic Microscopy, a new imaging technology applied to nanotechnology and life

Tristan Colomb, Frédéric Montfort, Stéphane Bourquin, Etienne Cuche, Christian Depeursinge, Pierre Marquet, Nicolas Aspert, Jonas Kühn, Florian Charrière, Mihaela Marian, Pierre Magistretti

2005

International perspectives on engaging the public in neuroethics

Pierre Magistretti

With an ever-increasing understanding of the brain mechanisms associated with core human attributes and values, there is an increasing public interest in the results of neuroscience research and the ways in which that new knowledge will be used. Here, we p ...

2005

Metabolic activation pattern of distinct hippocampal subregions during spatial learning and memory retrieval

Pierre Magistretti, Luc Pellerin

Activation dynamics of hippocampal subregions during spatial learning and their interplay with neocortical regions is an important dimension in the understanding of hippocampal function. Using the (14C)-2-deoxyglucose autoradiographic method, we have chara ...

2005

Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking

Pierre Magistretti, Luc Pellerin

MCT2 is the main neuronal monocarboxylate transporter needed by neurons if they are to use lactate as an additional energy substrate. Previous evidence suggested that some MCT2 could be located in postsynaptic elements of glutamatergic synapses. Using post ...

2005

Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators

Pierre Magistretti, Luc Pellerin

Glutamate was previously shown to enhance aerobic glycolysis i.e. increase glucose utilization and lactate production with no change in oxygen levels, in mouse cortical astrocytes by a mechanism involving glutamate uptake. It is reported here that a simila ...

Wiley-Blackwell2005

Hypoxia/hypoglycemia preconditioning prevents the loss of functional electrical activity in organotypic slice cultures

Pierre Magistretti

In cerebral ischemic preconditioning (IPC), a first sublethal ischemia increases the resistance of neurons to a subsequent severe ischemia. Despite numerous studies, the mechanisms are not yet fully understood. Our goal is to develop an in vitro model of I ...

2005

Chloramphenicol decreases brain glucose utilization and modifies the sleep-wake cycle architecture in rats

Pierre Magistretti, Jean-Marie Petit

We studied the effects of chloramphenicol on brain glucose utilization and sleep-wake cycles in rat. After slightly anaesthetized animals were injected with [18F]fluoro-2-deoxy-D-glucose, we acquired time-concentration curves from three radiosensitive beta ...

Wiley-Blackwell2005

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