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Pierre Magistretti

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Related publications (180)

Amyloid-Beta Modifies Astrocytic Metabolic Phenotype

Pierre Magistretti, Hilal Lashuel, Igor Allaman, David Viertl

2009

Red blood cell structure and dynamics explored with digital holographic microscopy

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Pascal Jourdain, Daniel Boss, Benjamin Rappaz

2009

Spatial analysis of erythrocyte membrane fluctuations by digital holographic microscopy

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Annick Hoffmann, Daniel Boss, Benjamin Rappaz

Red blood cell (RBC) membrane fluctuations provide important insights into cell states. We present a spatial analysis of red blood cell membrane fluctuations by using digital holographic Microscopy (DHM). This interferometric and dye-free technique, posses ...

Elsevier2009

Deciphering neuron-glia compartmentalization in cortical energy metabolism

Pierre Magistretti, Renaud Jolivet

Energy demand is an important constraint on neural signaling. Several methods have been proposed to assess the energy budget of the brain based on a bottom-up approach in which the energy demand of individual biophysical processes are first estimated indep ...

2009

Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy

Tristan Colomb, Christian Depeursinge, Pierre Marquet, Jonas Kühn, Pierre Magistretti, Benjamin Rappaz, Viesturs Simanis, Elena Cano

Digital holography microscopy (DHM) is an optical technique which provides phase images yielding quantitative information about cell structure and cellular dynamics. Furthermore, the quantitative phase images allow the derivation of other parameters, inclu ...

SPIE Society of Photo-optical Instrumentation Engineers2009

Role of glutamate in neuron-glia metabolic coupling

Pierre Magistretti

The coupling between synaptic activity and glucose utilization (neurometabolic coupling) is a central physiologic principle of brain function that has provided the basis for 2-deoxyglucose-based functional imaging with positron emission tomography. Approxi ...

2009

Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala

Jean-Luc Martin, Pierre Magistretti, Igor Allaman

Accumulating evidence supports a role for brain-derived neurotrophic factor (BDNF) in depression. However, most of these studies have been performed in animal models that have a low face validity with regard to the human disease. Here, we examined the regu ...

2009

Neuroprotective role of lactate after cerebral ischemia

Pierre Magistretti, Rolf Gruetter, Hongxia Lei, Jonathan Thevenet

It is well established that lactate can be used as an energy substrate by the brain by conversion to pyruvate and a subsequent oxidation in the mitochondria. Knowing the need for readily metabolizable substrates directly after ischemia and the protective e ...

2009

Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness

Pierre Magistretti, Bernard Lanz, Rolf Gruetter, Jean-Marie Petit, Hanne Frenkel

Although glycogen (Glyc) is the main carbohydrate storage component, the role of Glyc in the brain during prolonged wakefulness is not clear. The aim of this study was to determine brain Glyc concentration ([]) and turnover time (tau) in euglycemic conscio ...

Elsevier2009

Alteration of brain glycogen turnover in the awake rat

Pierre Magistretti, Bernard Lanz, Rolf Gruetter, Jean-Marie Petit, Hanne Frenkel

Nature Publishing Group2009

Mechanisms Of Glycogen Metabolism Regulation In Astrocytes

Pierre Magistretti, Igor Allaman

2009

Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer

Christian Depeursinge, Pierre Marquet, Pierre Magistretti, Benjamin Rappaz

Red blood cell (RBC) parameters such as morphology, volume, refractive index, and hemoglobin content are of great importance for diagnostic purposes. Existing approaches require complicated calibration procedures and robust cell perturbation. As a result, ...

2008

Simultaneous cell morphometry and refractive index measurement with dual- wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium

Christian Depeursinge, Pierre Marquet, Florian Charrière, Pierre Magistretti, Benjamin Rappaz

Digital holographic microscopy (DHM) allows optical-path-difference (OPD) measurements with nanometric accuracy. OPD induced by transparent cells depends on both the refractive index (RI) of cells and their morphology. This Letter presents a dual-wavelengt ...

2008

Functional imaging studies of cognition using Tc-99m-HMPAO SPECT: empirical validation using the n-back working memory paradigm

Pierre Magistretti

Purpose Functional activation protocols are widely applied for the study of brain-cognition relations. Only few take advantage of the intrinsic characteristics of SPECT, particularly those allowing cognitive assessment outside of the camera, in settings cl ...

Springer Verlag2008

Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study

Pierre Magistretti, Stephanie Clarke, Luc Pellerin

The monocarboxylate transporter MCT2 belongs to a large family of membrane proteins involved in the transport of lactate, pyruvate and ketone bodies. Although its expression in rodent brain has been well documented, the presence of MCT2 in the human brain ...

2008

Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-11C-acetate

Pierre Magistretti, Luc Pellerin

The purpose of this study was to investigate astrocytic oxidative metabolism using 1-(11)C-acetate. 1-(11)C-acetate kinetics were evaluated in the rat somatosensory cortex using a beta-scintillator during different manipulations (test-retest, infraorbital ...

2008

Long-term monitoring of post-stroke plasticity after transient cerebral ischemia in mice using in vivo and ex vivo diffusion tensor MRI

Pierre Magistretti

WE USED A MURINE MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA TO STUDY: 1) in vivo DTI long-term temporal evolution of the apparent diffusion coefficient (ADC) and diffusion fractional anisotropy (FA) at days 4, 10, 15 and 21 after stroke 2) ex vivo distribu ...

2008

Expression of genes related to brain energy metabolism following pharmacological and instrumental short sleep deprivation

Sylvain Eric Lengacher, Pierre Magistretti, Jean-Marie Petit, Sophie Burlet Godinot

2008

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

Pierre Magistretti, Igor Allaman

Astrocytes play an important role in nervous system homeostasis. In particular, they contribute to the regulation of local energy metabolism and to oxidative stress defence. In previous experiments, we showed that long-term treatment with interleukin 1alph ...

2008

Activity-dependent regulation of energy metabolism by astrocytes: an update

Pierre Magistretti, Luc Pellerin

Astrocytes play a critical role in the regulation of brain metabolic responses to activity. One detailed mechanism proposed to describe the role of astrocytes in some of these responses has come to be known as the astrocyte-neuron lactate shuttle hypothesi ...

2007

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