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Nicolas Kunz

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Related publications (32)

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Music enhances structural maturation of emotional processing neural pathways in very preterm infants

François Lazeyras, Nicolas Kunz

Prematurity disrupts brain maturation by exposing the developing brain to different noxious stimuli present in the neonatal intensive care unit (NICU) and depriving it from meaningful sensory inputs during a critical period of brain development, leading to ...

2020

Biophysical Basis of the Diffusion-Weighted Magnetic Resonance Signal in the Rat Brain

Nicolas Kunz

Nuclear magnetic resonance (NMR) can be used in-vivo in a vast array of applications, such as anatomical imaging (magnetic resonance imaging, MRI), localized chemical composition characterization (magnetic resonance spectroscopy, MRS), cellular structure a ...

EPFL2010

Design of an elastic porous injectable biomaterial for tissue regeneration and volume retention

Nicolas Kunz, Martina Genta

Soft tissue reconstruction currently relies on two main approaches, one involving the implantation of ex-ternal biomaterials and the second one exploiting surgical autologous tissue displacement. While both methods have different advantages and disadvantag ...

ELSEVIER SCI LTD2022

Developmental and metabolic brain alterations in rats exposed to bisphenol A during gestation and lactation

Rolf Gruetter, Nicolas Kunz

In recent years, considerable research has focused on the biological effect of endocrine-disrupting chemicals. Bisphenol A (BPA) has been implicated as an endocrine-disrupting chemical (EDC) due to its ability to mimic the action of endogenous estrogenic h ...

Elsevier2011

Intra- and extra-axonal axial diffusivities in the white matter: Which one is faster?

Nicolas Kunz, Ileana Ozana Jelescu, Analina Raquel Hausin

A two-compartment model of diffusion in white matter, which accounts for intra- and extra-axonal spaces, is associated with two plausible mathematical scenarios: either the intra-axonal axial diffusivity Da,‖ is higher than the extra-axonal De,‖ (Branch 1) ...

2018

Investigation of field and diffusion time dependence of the diffusion-weighted signal at ultrahigh magnetic fields

Rolf Gruetter, Yohan Van de Looij, Nicolas Kunz

Over the last decade, there has been a significant increase in the number of high-magnetic-field MRI magnets. However, the exact effect of a high magnetic field strength (B0 ) on diffusion-weighted MR signals is not yet fully understood. The goal of this s ...

Wiley-Blackwell2013

MarrowQuantAcross Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections

Nicolas Kunz, Olaia Maria Naveiras Torres-Quiroga, Olivier Burri, Josefine Catharina Pedersen Tratwal, Vasco Ledebur de Antas de Campos, Rita Sarkis, Frédérica Schyrr, Shanti Rojas-Sutterlin, Daniel Naveed Tavakol

The bone marrow (BM) exists heterogeneously as hematopoietic/red or adipocytic/yellow marrow depending on skeletal location, age, and physiological condition. Mouse models and patients undergoing radio/chemotherapy or suffering acute BM failure endure rapi ...

2020

Assessing white matter microstructure of the newborn with multi-shell diffusion MRI and biophysical compartment models

François Lazeyras, Nicolas Kunz, Hui Zhang, Kieran O'Brien

Brain white matter connections have become a focus of major interest with important maturational processes occurring in newborns. To study the complex microstructural developmental changes in-vivo, it is imperative that non-invasive neuroimaging approaches ...

Elsevier2014

Diffusion-Weighted Spectroscopy: A Novel Approach to Determine Macromolecule Resonances in Short-Echo Time H-1-MRS

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Nicolas Kunz

Quantification of short-echo time proton magnetic resonance spectroscopy results in >18 metabolite concentrations (neurochemical profile). Their quantification accuracy depends on the assessment of the contribution of macromolecule (MM) resonances, previou ...

Wiley-Blackwell2010

Refined Analysis of Brain Energy Metabolism Using In Vivo Dynamic Enrichment of 13C Multiplets

João Miguel das Neves Duarte, Rolf Gruetter, Bernard Lanz, Nicolas Kunz, Masoumeh Dehghani Moghadam

Carbon-13 nuclear magnetic resonance spectroscopy in combination with the infusion of (13)C-labeled precursors is a unique approach to study in vivo brain energy metabolism. Incorporating the maximum information available from in vivo localized (13)C spect ...

Sage Publications Ltd2016

Unified multi-modal characterization of microstructural parameters of brain tissue using diffusion MRI and multi-echo T2 data

Jean-Philippe Thiran, Alessandro Daducci, Erick Jorge Canales Rodriguez, Nicolas Kunz, Marco Pizzolato

In this study, a unified framework to estimate different microstructure indices from diffusion MRI and multi-echo T2 (MET2) data was proposed.The new methodology takes into account the common and complementary information provided by both modalities. While ...

2018

Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging

Jean-Philippe Thiran, Alessandro Daducci, François Lazeyras, Nicolas Kunz, Alia Lemkaddem

Focal epilepsy is increasingly recognized as the result of an altered brain network, both on the structural and functional levels and the characterization of these widespread brain alterations is crucial for our understanding of the clinical manifestation ...

2014

Comparison of non-parametric T2 relaxometry methods for myelin water quantification

Jean-Philippe Thiran, Tobias Kober, Alessandro Daducci, Tom Hilbert, Erick Jorge Canales Rodriguez, Nicolas Kunz, Marco Pizzolato, Gian Franco Piredda, Thomas Yu

Multi-component T2 relaxometry allows probing tissue microstructure by assessing compartment-specific T2 relaxation times and water fractions, including the myelin water fraction. Non-negative least squares (NNLS) with zero-order Tikhonov regularization is ...

2021

Diffusion-weighted MRS of acetate in the rat brain

Rolf Gruetter, Bernard Lanz, Hikari Ananda Infinity Yoshihara, Nicolas Kunz, Masoumeh Dehghani Moghadam

Acetate has been proposed as an astrocyte-specific energy substrate for metabolic studies in the brain. The determination of the relative contribution of the intracellular and extracellular compartments to the acetate signal using diffusion-weighted magnet ...

Wiley-Blackwell2017

Fast Bias Field Correction for 9.4 Tesla Magnetic Resonance Imaging

Jean-Philippe Thiran, Rolf Gruetter, Murat Kunt, Meritxell Bach Cuadra, Nicolas Kunz, Nathalie Just

In this paper the problem of intensity inhomogeneity at high magnetic field on magnetic resonance images is addressed. Specifically, rat brain images at 9.4T acquired with a surface coil are bias corrected. We propose a low- pass frequency model that takes ...

2008

Neuronal energy metabolism in the mouse brain measured by H-1-[C-13] MRS at 14.1T under [3-C-13]-Lactate infusion: a feasibility study

Lijing Xin, Hongxia Lei, Bernard Lanz, Nicolas Kunz

SAGE PUBLICATIONS INC2019

MarrowQuant across Aging and Aplasia: A Digital Pathology Tool for Quantification of Bone Marrow Compartments in Histological Sections

Nicolas Kunz, Olaia Maria Naveiras Torres-Quiroga, Olivier Burri, Josefine Catharina Pedersen Tratwal, Vasco Ledebur de Antas de Campos, Rita Sarkis, Frédérica Schyrr, Shanti Rojas-Sutterlin

WILEY2020

Diffusion Tensor Echo Planar Imaging Using Surface Coil Transceiver with a Semiadiabatic RF Pulse Sequence at 14.1T

Rolf Gruetter, Yohan Van de Looij, Nicolas Kunz

Diffusion magnetic resonance studies of the brain are typically performed using volume coils. Although in human brain this leads to a near optimal filling factor, studies of rodent brain must contend with the fact that only a fraction of the head volume ca ...

Wiley-Blackwell2011

Diffusion behavior of cerebral metabolites of congenital portal systemic shunt mice assessed noninvasively by diffusion-weighted H-1 magnetic resonance spectroscopy

Hongxia Lei, Nicolas Kunz, Masoumeh Dehghani Moghadam

Diffusion-weighted H-1-MRS (DW-MRS) allows for noninvasive investigation of the cellular compartmentalization of cerebral metabolites. DW-MRS applied to the congenital portal systemic shunt (PSS) mouse brain may provide specific insight into alterations of ...

2019

Definition and quantification of acute inflammatory white matter injury in the immature brain by MRI/MRS at high magnetic field

Rolf Gruetter, Nicolas Kunz

Background: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementat ...

Nature Publishing Group2014