Publications by Nicolas Kunz | EPFL Graph Search

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Prematurity disrupts brain maturation by exposing the developing brain to different noxious stimuli present in the neonatal intensive care unit (NICU) and depriving it from meaningful sensory inputs during a critical period of brain development, leading to ...

Nuclear magnetic resonance (NMR) can be used in-vivo in a vast array of applications, such as anatomical imaging (magnetic resonance imaging, MRI), localized chemical composition characterization (magnetic resonance spectroscopy, MRS), cellular structure a ...

Soft tissue reconstruction currently relies on two main approaches, one involving the implantation of ex-ternal biomaterials and the second one exploiting surgical autologous tissue displacement. While both methods have different advantages and disadvantag ...

In recent years, considerable research has focused on the biological effect of endocrine-disrupting chemicals. Bisphenol A (BPA) has been implicated as an endocrine-disrupting chemical (EDC) due to its ability to mimic the action of endogenous estrogenic h ...

A two-compartment model of diffusion in white matter, which accounts for intra- and extra-axonal spaces, is associated with two plausible mathematical scenarios: either the intra-axonal axial diffusivity Da,‖ is higher than the extra-axonal De,‖ (Branch 1) ...

Over the last decade, there has been a significant increase in the number of high-magnetic-field MRI magnets. However, the exact effect of a high magnetic field strength (B0 ) on diffusion-weighted MR signals is not yet fully understood. The goal of this s ...

The bone marrow (BM) exists heterogeneously as hematopoietic/red or adipocytic/yellow marrow depending on skeletal location, age, and physiological condition. Mouse models and patients undergoing radio/chemotherapy or suffering acute BM failure endure rapi ...

Brain white matter connections have become a focus of major interest with important maturational processes occurring in newborns. To study the complex microstructural developmental changes in-vivo, it is imperative that non-invasive neuroimaging approaches ...

Quantification of short-echo time proton magnetic resonance spectroscopy results in >18 metabolite concentrations (neurochemical profile). Their quantification accuracy depends on the assessment of the contribution of macromolecule (MM) resonances, previou ...

Carbon-13 nuclear magnetic resonance spectroscopy in combination with the infusion of (13)C-labeled precursors is a unique approach to study in vivo brain energy metabolism. Incorporating the maximum information available from in vivo localized (13)C spect ...

Focal epilepsy is increasingly recognized as the result of an altered brain network, both on the structural and functional levels and the characterization of these widespread brain alterations is crucial for our understanding of the clinical manifestation ...

Acetate has been proposed as an astrocyte-specific energy substrate for metabolic studies in the brain. The determination of the relative contribution of the intracellular and extracellular compartments to the acetate signal using diffusion-weighted magnet ...

Myelin water imaging is an MRI technique used to quantify myelination in the brain. The state-of-the-art reconstruction method is based on non-negative least squares optimization with zero-order Tikhonov regularization. In this study, a second-order Tikhonov regularization approach with control points was examined. This penalty term is more efficient for promoting smooth solutions while minimizing the contamination between myelin and non-myelin components. The performance of the proposed algorithm was inves

Diffusion magnetic resonance studies of the brain are typically performed using volume coils. Although in human brain this leads to a near optimal filling factor, studies of rodent brain must contend with the fact that only a fraction of the head volume ca ...

Diffusion-weighted H-1-MRS (DW-MRS) allows for noninvasive investigation of the cellular compartmentalization of cerebral metabolites. DW-MRS applied to the congenital portal systemic shunt (PSS) mouse brain may provide specific insight into alterations of ...

Background: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementat ...

The recent developments in high magnetic field (13) C magnetic resonance spectroscopy with improved localization and shimming techniques have led to important gains in sensitivity and spectral resolution of (13) C in vivo spectra in the rodent brain, enabl ...

Nicolas Kunz

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Music enhances structural maturation of emotional processing neural pathways in very preterm infants

Biophysical Basis of the Diffusion-Weighted Magnetic Resonance Signal in the Rat Brain

Design of an elastic porous injectable biomaterial for tissue regeneration and volume retention

Developmental and metabolic brain alterations in rats exposed to bisphenol A during gestation and lactation

Intra- and extra-axonal axial diffusivities in the white matter: Which one is faster?

Investigation of field and diffusion time dependence of the diffusion-weighted signal at ultrahigh magnetic fields

MarrowQuantAcross Aging and Aplasia: A Digital Pathology Workflow for Quantification of Bone Marrow Compartments in Histological Sections

Assessing white matter microstructure of the newborn with multi-shell diffusion MRI and biophysical compartment models

Diffusion-Weighted Spectroscopy: A Novel Approach to Determine Macromolecule Resonances in Short-Echo Time H-1-MRS

Refined Analysis of Brain Energy Metabolism Using In Vivo Dynamic Enrichment of 13C Multiplets

Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging

Diffusion-weighted MRS of acetate in the rat brain

MarrowQuant across Aging and Aplasia: A Digital Pathology Tool for Quantification of Bone Marrow Compartments in Histological Sections

Robust myelin water imaging from multi-echo T2 data using second-order Tikhonov regularization with control points

Diffusion Tensor Echo Planar Imaging Using Surface Coil Transceiver with a Semiadiabatic RF Pulse Sequence at 14.1T

Diffusion behavior of cerebral metabolites of congenital portal systemic shunt mice assessed noninvasively by diffusion-weighted H-1 magnetic resonance spectroscopy

Definition and quantification of acute inflammatory white matter injury in the immature brain by MRI/MRS at high magnetic field

Assessment Of Cerebral Osmotic Regulation In A Rat Model Of Biliary Cirrhosis Using MR Spectroscopy

Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES

In vivo longitudinal 1H Spectroscopic Imaging and Diffusion Tensor Imaging studies at 9.4T in a rat model of chronic liver failure