Publications by Geoffrey Bodenhausen

Related publications (143)

Challenges in preparing, preserving and detecting para-water in bulk: overcoming proton exchange and other hurdles

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Diego Carnevale, Daniele Mammoli, Nicola Salvi, Roberto Buratto, Estel Canet Martinez

Para-water is an analogue of para-hydrogen, where the two proton spins are in a quantum state that is antisymmetric under permutation, also known as singlet state. The populations of the nuclear spin states in para-water are believed to have long lifetimes ...

Royal Society of Chemistry2015

Broadband excitation in solid-state NMR using interleaved DANTE pulse trains with N pulses per rotor period

Geoffrey Bodenhausen, Diego Carnevale, Simone Ulzega

We analyze the direct excitation of wide one-dimensional spectra of nuclei with spin I = 1/2 or 1 in rotating solids submitted to pulse trains in the manner of Delays Alternating with Nutations for Tailored Excitation (DANTE), either with one short rotor-s ...

Academic Press Inc - Elsevier Science2013

A spinning thermometer to monitor microwave heating and glass transitions in dynamic nuclear polarization

Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Pascal Miéville, Marc Anthony Caporini

As previously demonstrated by Thurber and Tycko, the peak position of Br-79 in potassium bromide (KBr) allows one to determine the temperature of a spinning sample. We propose to adapt the original design by using a compact KBr tablet placed at the bottom ...

Wiley-Blackwell2011

Determination of transverse relaxation rates in systems with scalar-coupled spins: The role of antiphase coherences

Geoffrey Bodenhausen

Homogeneous line-widths that arise from transverse relaxation tend to be masked by B-0 field inhomogeneity and by multiplets due to homonuclearf-couplings. Besides well-known spin-locking sequences that lead to signals that decay with a rate R-1p without a ...

Academic Press Inc - Elsevier Science2013

Nanosecond Time Scale Motions in Proteins Revealed by High-Resolution NMR Relaxometry

Geoffrey Bodenhausen

Understanding the molecular determinants underlying protein function requires the characterization of both structure and dynamics at atomic resolution. Nuclear relaxation rates allow a precise characterization of protein dynamics at the Larmor frequencies ...

American Chemical Society2013

Fast Proton Exchange in Histidine: Measurement of Rate Constants through Indirect Detection by NMR Spectroscopy

Geoffrey Bodenhausen

Owing to its imidazole side chain, histidine participates in various processes such as enzyme catalysis, pH regulation, metal binding, and phosphorylation. The determination of exchange rates of labile protons for such a system is important for understandi ...

Wiley-Blackwell2014

Efficient heteronuclear decoupling by quenching rotary resonance in solid-state NMR

Geoffrey Bodenhausen

A method for heteronuclear decoupling in fast magic-angle spinning NMR measurements comprises application of a decoupling RF-pulse sequence with a decoupling-field amplitude 1⁄2 1 I on spins of a first nucleus and of an excitation pulse on spins of a secon ...

2008

Long-Lived States of Magnetically Equivalent Spins Populated by Dissolution-DNP and Revealed by Enzymatic Reactions

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Daniele Mammoli, Xiao Ji

Hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) offers a way of enhancing NMR signals by up to five orders of magnitude in metabolites and other small molecules. Nevertheless, the lifetime of hyperpolarization is inexorably limited, a ...

Wiley-Blackwell2014

Three-field NMR to preserve hyperpolarized proton magnetization as long-lived states in moderate magnetic fields

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

This communication describes a three-field experiment where inequivalent scalar coupled spin pairs are hyperpolarized at 3.35 T and 1.2 K by dynamic nuclear polarization (DNP), rapidly transferred to high field (7 T) to prepare a suitable initial condition ...

Elsevier2011

Apparent Transverse Relaxation Rates in Systems with Scalar-Coupled Protons

Geoffrey Bodenhausen

The modulation of spin echoes by homonuclear scalar couplings render the determination of transverse relaxation rates of individual spins difficult, in particular for molecules that are isotopically enriched in 13C or 15N, and for all molecules with scalar ...

2009

Phenylazide Hybrid-Silica - Polarization Platform for Dynamic Nuclear Polarization at Cryogenic Temperatures

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

Hyperpolarization of NMR-active nuclei is key to gather high quality spectra of rare species and insensitive isotopes. We have recently established that silica-based materials containing regularly distributed nitroxyl radicals connected to the silica matri ...

Wiley-V C H Verlag Gmbh2017

Deuterium MAS NMR Studies of Dynamics on Multiple Timescales: Histidine and Oxalic Acid

Geoffrey Bodenhausen

Deuterium (H-2) magic-angle spinning (MAS) nuclear magnetic resonance is applied to monitor the dynamics of the exchanging labile deuterons of polycrystalline L-histidine hydrochloride monohydrate-d(7) and -oxalic acid dihydrate-d(6). Direct experimental e ...

Wiley-Blackwell2015

Cross Polarization for Dissolution Dynamic Nuclear Polarization Experiments at Readily Accessible Temperatures 1.2 < T < 4.2 K

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet

Cross polarization can provide significant enhancements with respect to direct polarization of low-gamma nuclei such as C-13. Substantial gains in sample throughput (shorter polarization times) can be achieved by exploiting shorter build-up times tau(DNP)( ...

Springer Verlag2012

Kinetics of RNA Refolding in Dynamic Equilibrium by 1H-Detected 15N Exchange NMR Spectroscopy

Geoffrey Bodenhausen, Philipp Wenter

By implementing new NMR methods that were designed to map very slow exchange processes we have investigated and characterized the refolding kinetics of a thermodynamically stable 34mer RNA sequence in dynamic equilibrium. The RNA sequence was designed to u ...

2006

Exchange Rate Constants of Invisible Protons in Proteins Determined by NMR Spectroscopy

Geoffrey Bodenhausen

Although labile protons that are exchanging rapidly with those of the solvent cannot be observed directly, their exchange rate constants can be determined by indirect detection of scalar-coupled neighboring nuclei. We have used heteronuclear NMR spectrosco ...

2008

Predicting conformational entropy of bond vectors in proteins by networks of coupled rotators

Geoffrey Bodenhausen

In this article, a formal expression for the conformational entropy of a bond vector in a protein is derived using the networks of coupled rotators model for the description of internal dynamics. Analytical relationships between NMR order parameters and co ...

American Institute of Physics2008

Heteronuclear Double Resonance in NMR Spectroscopy: Relaxation of Multiple Quantum Coherences

Geoffrey Bodenhausen, Simone Ulzega, Mariachiara Verde

Theoretical and experimental investigations of the relaxation rates of multiple-quantum coherences during heteronuclear double resonance (HDR) pulse sequences are presented. Average Liouvillian theory yields analytical expressions to describe the effective ...

2009

Multiple-Timescale Dynamics of Side-Chain Carboxyl and Carbonyl Groups in Proteins by C-13 Nuclear Spin Relaxation

Geoffrey Bodenhausen

Side-chain carboxyl and carbonyl groups play a major role in protein interactions and enzyme catalysis. A series of C-13 relaxation experiments is introduced to study the dynamics of carboxyl and carbonyl groups in protein side chains on both fast (sub-ns) ...

American Chemical Society2008

Broadband excitation and indirect detection of nitrogen-14 in rotating solids using Delays Alternating with Nutation (DANTE)

Geoffrey Bodenhausen, Marc Anthony Caporini, Simone Ulzega

A train of short rotor-synchronized pulses in the manner of Delays Alternating with Nutations for Tailored Excitation (DANTE) applied to nitrogen-14 nuclei (I = 1) in samples spinning at the magic angle at high frequencies (typically nu(rot) = 62.5 kHz so ...

Academic Press Inc - Elsevier Science2011

Hybrid polarizing solids for pure hyperpolarized liquids through dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, David Lyndon Emsley, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in ...

National Academy of Sciences2014