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Martinus Adela Maria Gijs

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Related publications (362)

Page 2 of 19

Effect of inoculum size and antibiotics on bacterial traveling bands in a thin microchannel defined by optical adhesive

Martinus Adela Maria Gijs, Thomas Lehnert

Phenotypic diversity in bacterial flagella-induced motility leads to complex collective swimming patterns, appearing as traveling bands with transient locally enhanced cell densities. Traveling bands are known to be a bacterial chemotactic response to self ...

SPRINGERNATURE2021

Efficient AC electrothermal flow (ACET) on-chip for enhanced immunoassays

Martinus Adela Maria Gijs, Diego Gabriel Dupouy, Muaz Salama Abdelmonem Draz

Biochemical reaction rates in microfluidic systems are known to be limited by the diffusional transport of reagents, leading often to lowered sensitivity and/or longer detection times in immunoassays. Several methods, including electrically powering electr ...

ROYAL SOC CHEMISTRY2023

Assessment of the baseline scenario at q(95) similar to 3 for ITER

Olivier Sauter, Martinus Adela Maria Gijs, Jonathan Graves, Ambrogio Fasoli, Stefano Coda, Basil Duval, Henri Weisen, Richard Pitts, Yves Martin, Javier García Hernández, Duccio Testa, Miguel Fernández Ruiz, Nicola Vianello, Robin Humphry-Baker, Sun Hee Kim, Federico Nespoli, Patrick Blanchard, Alessandro Pau, David Pfefferlé, Davide Galassi, Jonathan Marc Philippe Faustin, Cristian Sommariva, Hamish William Patten, Samuel Lanthaler, Jan Horacek, Yann Camenen, Bruno Emanuel Ferreira De Sousa Correia, José Pedro Rebelo Ferreira Marques, Mikhail Maslov, Marco Wischmeier, Dalziel Joseph Wilson, Liang Yao, Daniel Scott Alessi, Arnout Lodewijk M Beckers, Ana Francisca Leal Silva Soares, Jonnathan Cesar Hidalgo Acosta, Antonio José Pereira de Figueiredo, Partha Dutta, Pierre-Thomas Paul Brun, Pedro Camilo de Oliveira e Silva, Alberto Hernando de Castro, Julio Rodriguez, Vlad Trifa, Li Shuai, Rebecca Hill

The International Tokamak Physics Activity topical group on integrated operational scenarios has compiled a database of stationary H-mode discharges at q(95) similar to 3 from AUG, C-Mod, DIII-D, JET and JT-60U, for both carbon wall and high-Z metal wall e ...

IOP Publishing Ltd2018

Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms

Martinus Adela Maria Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Elena Katsyuba, Hüseyin Baris Atakan, Rongrong Xiang

The nematode Caenorhabditis elegans is a suitable model organism in drug screening. Traditionally worms are grown on agar plates, posing many challenges for long-term culture and phenotyping of animals under identical conditions. Microfluidics allows for ' ...

Nature Research2019

Photonic Nanojet Array for Fast Detection of Single Nanoparticles in a Flow

Martinus Adela Maria Gijs, Matteo Cornaglia, Hui Yang

We detect by optical microscopy Au and fluorescent nanopartides (NPs) during their motion in water based medium, using an array of dielectric microspheres that are patterned in a microwell array template. The Microspheres act as lenses focusing the light o ...

American Chemical Society2015

Magnetic beads retention device for sandwich immunoassay: comparison of off-chip and on-chip antibody incubation

Martinus Adela Maria Gijs, Caroline Vandevyver, Frédéric Lacharme

We use magnetic microbeads, which are magnetically self-assembled in chains in a microfluidic chip, as reaction substrates to implement two different sandwich immunoassay protocols for the detection of mouse monoclonal target antibodies. The magnetic chain ...

Springer-Verlag2009

Microfluidics-assisted multiplexed biomarker detection for in situ mapping of immune cells in tumor sections

Martinus Adela Maria Gijs, Daniel Migliozzi, Diego Gabriel Dupouy, Benjamin Pelz

Because of the close interaction between tumors and the immune system, immunotherapies are nowadays considered as the most promising treatment against cancer. In order to define the diagnosis and the subsequent therapy, crucial information about the immune ...

2019

Multimodal imaging and high-throughput image-processing for drug screening on living organisms on-chip

Michaël Unser, Martinus Adela Maria Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Daniel Migliozzi, Virginie Sophie Uhlmann

A major step for the validation of medical drugs is the screening on whole organisms, which gives the systemic information that is missing when using cellular models. Caenorhabditis elegans is a soil worm that catches the interest of researchers who study ...

SPIE Society of Photo-optical Instrumentation Engineers2019

Nonlinear dynamic analysis of D-alpha signals for type I edge localized modes characterization on JET with a carbon wall

Olivier Sauter, Martinus Adela Maria Gijs, Ambrogio Fasoli, Stefano Coda, Basil Duval, Henri Weisen, Richard Pitts, Yves Martin, Javier García Hernández, Duccio Testa, Miguel Fernández Ruiz, Robin Humphry-Baker, Sun Hee Kim, Federico Nespoli, Patrick Blanchard, David Pfefferlé, Jonathan Marc Philippe Faustin, Jan Horacek, Bruno Emanuel Ferreira De Sousa Correia, Jonathan Graves, José Pedro Rebelo Ferreira Marques, Mikhail Maslov, Marco Wischmeier, Dalziel Joseph Wilson, Liang Yao, Jonnathan Cesar Hidalgo Acosta, Antonio José Pereira de Figueiredo, Partha Dutta, Pierre-Thomas Paul Brun, Pedro Camilo de Oliveira e Silva, Vlad Trifa, Rebecca Hill, Joan Decker, Cristian Galperti, Andrea Scarabosio, Gilles Arnoux, Daniel Filipe Dos Santos Alves Jana, Thomas Jean F Bauwens

In this paper, the dynamic characteristics of type-I ELM time-series from the JET tokamak, the world's largest magnetic confinement plasma physics experiment, have been investigated. The dynamic analysis has been focused on the detection of nonlinear struc ...

2018

Escaping alpha-particle monitor for burning plasmas

This paper presents a diagnostic system, gamma-ray alpha-particle monitor (GRAM), for continuous monitoring of deuterium-tritium fusion alpha-particles in the MeV energy range escaped from the plasma to the first wall. The diagnostic is based on the detect ...

IOP Publishing Ltd2018

A microfluidic array for high-content screening at whole-organism resolution

Martinus Adela Maria Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Daniel Migliozzi

A main step for the development and the validation of medical drugs is the screening on whole organisms, which gives the systemic information that is missing when using cellular models. Among the organisms of choice, Caenorhabditis elegans is a soil worm w ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Bubble-enhanced ultrasonic microfluidic chip for rapid DNA fragmentation

Martinus Adela Maria Gijs, Thomas Lehnert

DNA fragmentation is an essential process in developing genetic sequencing strategies, genetic research, as well as for the diagnosis of diseases with a genetic signature like cancer. Efficient on-chip DNA fragmentation protocols would be beneficial to pro ...

ROYAL SOC CHEMISTRY2022

Correlation of surface chemical states with hydrogen isotope retention in divertor tiles of JET with ITER-Like Wall

To understand the fuel retention mechanism correlation of surface chemical states and hydrogen isotope retention behavior determined by XPS (X-ray photoelectron spectroscopy) and TDS (Thermal desorption spectroscopy), respectively, for JET ITER-Like Wall s ...

ELSEVIER SCIENCE SA2018

On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites

Martinus Adela Maria Gijs, Thomas Lehnert, Matteo Cornaglia, Li Dong

Like other animals, C. elegans nematodes have the ability to socially interact and to communicate through exchange and sensing of small soluble signaling compounds that help them cope with complex environmental conditions. For the time being, worm biocommu ...

Royal Soc Chemistry2016

An assessment of nitrogen concentrations from spectroscopic measurements in the JET and ASDEX upgrade divertor

The impurity concentration in the tokamak divertor plasma is a necessary input for predictive scaling of divertor detachment, however direct measurements from existing tokamaks in different divertor plasma conditions are limited. To address this, we have a ...

Elsevier2019

Activation Inventories After Exposure To Dd/Dt Neutrons In Safety Analysis Of Nuclear Fusion Installations

Irradiations with 14 MeV fusion neutrons are planned at Joint European Torus (JET) in DT operations with the objective to validate the calculation of the activation of structural materials in functional materials expected in ITER and fusion plants. This st ...

2018

Continuous quantification of HER2 expression by microfluidic precision immunofluorescence estimates HER2 gene amplification in breast cancer

Martinus Adela Maria Gijs, Ata Tuna Ciftlik, Diego Gabriel Dupouy

Chromogenic immunohistochemistry (IHC) is omnipresent in cancer diagnosis, but has also been criticized for its technical limit in quantifying the level of protein expression on tissue sections, thus potentially masking clinically relevant data. Shifting f ...

Nature Research2016

Microfluidic-based immunohistochemistry for breast cancer diagnosis: a comparative clinical study

Fabio Aimi, Martinus Adela Maria Gijs, Diego Gabriel Dupouy, Saska Brajkovic

Breast cancer is a highly heterogeneous disease. The efficacy of tailored therapeutic strategies relies on the precise detection of diagnostic biomarkers by immunohistochemistry (IHC). Therefore, considering the increasing incidence of breast cancer cases, ...

2019

Radial variation of heat transport in L-mode JET discharges

In this paper, we analyze heat transport in the JET tokamak using data from its high resolution ECE diagnostic and analyses based on the transfer entropy (TE). The analysis reveals that heat transport is not smooth and continuous, but is characterized by ' ...

IOP Publishing Ltd2019

Dose-response curve of a microfluidic magnetic bead-based surface coverage sandwich assay

Martinus Adela Maria Gijs, Thomas Lehnert, Matteo Cornaglia, Hüseyin Cumhur Tekin, Raphaël Etienne Jean Trouillon

Magnetic micro-and nanoparticles ('magnetic beads') have been used to advantage in many microfluidic devices for sensitive antigen (Ag) detection. Today, assays that use as read-out of the signal the number count of immobilized beads on a surface for quant ...

Elsevier2015