Publications by Jacques Josserand

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On-column conductivity detection in capillary-chip electrophoresis was achieved by actively coupling the high electric field with two sensing electrodes connected to the main capillary channel through two side detection channels. The principle of this conc ...

Ionic transport in charged conical nanopores is known to give rise to ion current rectification. The present study shows that the rectification direction can be inverted when using electrolyte solutions at very low ionic strengths. To elucidate these pheno ...

The Off-Gel™ technology was recently described for protein fractionation in a solution placed on top of an immobilized pH gradient gel. In addition, this process was found to remove salts from the biological samples to analyze. This desalting effect is stu ...

When two electrolyte solutions of different temperature are placed in contact, a thermal diffusion potential (TDP) is established. The phenomenon is studied numerically using finite element simulations of the temperature distribution within a hydrodynamic cell. Experimentally, the hydrovoltaic flow cell is used to demonstrate how a temperature difference can induce redox reactions at electrodes placed in the two liquids in order to extract a current continuously in an external circuit resulting in a power-g

A sandwich mixer consists of mixing two solutions in a channel, one central laminar flow being sandwiched between two outer flow solutions. The present numerical study considers the convection– diffusion of two reacting species A and B, provided respective ...

Finite element numerical simulations were carried out in 2D geometries to map the magnetic field and force distribution produced by rectangular permanent magnets as a function of their size and position with respect to a microchannel. A single magnet, two ...

An automated fraction collection interface has been developed for coupling capillary electrophoresis (CE) with matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). This fraction collection approach is based on electromigration and diff ...

This paper introduces the concept of ring magnets for magnetic beads (MBs) trapping in a capillary. Such magnets enable an easy insertion of a capillary simply like a pearl on a string. With this system, high magnetic forces are obtained thanks to the prox ...

In proteomic analysis of complex samples at the peptide level (termed shotgun proteomics), an effective prefractionation is crucial to decrease the complexity of the peptide mixture for further analysis. In this perspective, the high-resolving power of the ...

A numerical model for the adsorption kinetics of proteins on the walls of a microchannel has been developed using the finite element method (FEM) to address the coupling with diffusion phenomena in the restricted microchannel volume. Time evolutions of the ...

Magnetism-based microsystems, as those dedicated to immunoaffinity separations or (bio)chemical reactions, take benefit of the large surface area-to-volume ratio provided by the immobilized magnetic beads, thus increasing the sensitivity of the analysis. A ...

On-line electrogeneration of mass tags in a microspray emitter is used to quantify the number of cysteine groups in a given peptide. A finite-element simulation of the multi-step process yields the relative distribution and concentration of tags, untagged ...

A finite element simulation has been used in order to study the partition chromatography process of one species between an aqueous mobile phase and an organic stationary phase located at the bottom of a rectangular microchannel. The transient model incorpo ...

This work addresses two ways of loading proteins on microchannel surfaces for immunoassay applications: the “stop-flow” and the continuous flow processes. The “stop-flow” method consists of successive static incubation periods where the bulk solution deple ...

Jacques Josserand

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On-column conductivity detection in capillary-chip electrophoresis

Ion current rectification and rectification inversion in conical nanopores: a perm-selective view

Salt Removal During Off-GelTM Electrophoresis of Protein Samples

Hydrovoltaic cells. Part II: Thermogalvanic cells and numerical simulations of thermal diffusion potentials

Sandwich mixer–reactor: influence of the diffusion coefficient and flow rate ratios

Magnetic forces produced by rectangular permanent magnets in static microsystems

Iontophoretic Fraction Collection for Coupling Capillary Zone Electrophoresis with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Ring magnets for magnetic beads trapping in a capillary

Modeling the Isoelectric Focusing of Peptides in an OFFGEL Multicompartment Cell

Protein adsorption in static microsystems: effect of the surface to volume ratio

Magnetic track array for efficient bead capture in microchannels

Electrochemical Multi-Tagging of Cysteinyl Peptides during Microspray Mass Spectrometry: Numerical Simulation of Consecutive Reactions in a Microchannel

Numerical Simulation of Two-Phase Partition Chromatography in Microchannels for Moderated Log P Measurements

Dynamic protein adsorption in microchannels by "stop-flow" and continuous flow

Numerical simulations of linear scan anodic stripping voltammetry at a modified square array of hemispherical microelectrodes located in a thin-layer cell

Contact Galvani potential differences at liquid|liquid interfaces Part II. Contact diffusion potentials in microsystems

Finite Element Simulation of Ion Transfer Reactions at a Single Micro-Liquid/Liquid Interface Supported on a Thin Polymer Film

Contact Galvani potential differences at liquid | liquid interfaces Part I: Experimental studies on single salt distribution at liquid | liquid interfaces using a streaming technique

Hydro-voltaic cells. Part I. Concentration cells

Numerical Investigation of an Electrochemically Induced Tagging in a Nanospray for Protein Analysis