Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Lecture

Tissue Engineering: Organoids and Biomaterials

In course

MSE-471: Biomaterials (pour MX)

The course introduces the main classes of biomaterials used in the biomedical field. The interactions with biological environment are discussed and challenges highlighted. State of the art examples per type of material are discussed. Students will engineer ...

Description

This lecture covers the development and applications of organoids, 'mini' organs grown from stem cells, for modeling diseases, drug testing, and tissue regeneration. It also discusses the challenges and advancements in biomaterials for tissue engineering.

This video is available exclusively on Mediaspace for a restricted audience. Please log in to MediaSpace to access it if you have the necessary permissions.

Watch on Mediaspace

Instructor

Maartje Martina Cornelia Bastings

Official source

Ontological neighbourhood

Biological engineering

Biomedical engineering: Tissue engineering

Related concepts (21)

Adult stem cell

Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. Also known as somatic stem cells (from Greek σωματικóς, meaning of the body), they can be found in juvenile, adult animals, and humans, unlike embryonic stem cells. Scientific interest in adult stem cells is centered around two main characteristics.

Organoid

An organoid is a miniaturized and simplified version of an organ produced in vitro in three dimensions that mimics the key functional, structural and biological complexity of that organ. They are derived from one or a few cells from a tissue, embryonic stem cells or induced pluripotent stem cells, which can self-organize in three-dimensional culture owing to their self-renewal and differentiation capacities. The technique for growing organoids has rapidly improved since the early 2010s, and The Scientist names it as one of the biggest scientific advancements of 2013.

Stem-cell therapy

Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. , the only established therapy using stem cells is hematopoietic stem cell transplantation. This usually takes the form of a bone-marrow transplantation, but the cells can also be derived from umbilical cord blood. Research is underway to develop various sources for stem cells as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and heart disease.

Stem cell

In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms, but they have slightly different properties in each. They are usually distinguished from progenitor cells, which cannot divide indefinitely, and precursor or blast cells, which are usually committed to differentiating into one cell type.

Stem-cell niche

Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate cell fate. The word 'niche' can be in reference to the in vivo or in vitro stem-cell microenvironment. During embryonic development, various niche factors act on embryonic stem cells to alter gene expression, and induce their proliferation or differentiation for the development of the fetus.

Related lectures (32)

Organoids: Miniature Multicellular Tissue Constructs

Explores organoids, miniature tissue constructs mimicking living tissues, covering derivation methods, applications, and bridging in vitro and in vivo models.

Stem Cells and Organoid Engineering

Delves into the rise of organoids and gastruloids through stem cell cultivation, exploring the potential applications of human stem cells.

Stem Cell Biology: Essentials and Applications

Covers the essentials of stem cell biology, including major types, properties, and applications, as well as challenges in research.

Stem Cell Applications: Models, Therapy, and Cloning

Explores the applications of embryonic stem cells in biomedical research, disease modeling, and potential therapeutic interventions, including the types of stem cells and the challenges they face.

Organoids: Model Systems in Tissue Engineering