Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Lecture

Genetic Inheritance and X Chromosome Inactivation

In course

BIO-105: Cellular biology and biochemistry for engineers

Basic course in biochemistry as well as cellular and molecular biology for non-life science students enrolling at the Master or PhD thesis level from various engineering disciplines. It reviews essential notions necessary for a training in biology-related ...

Description

This lecture covers the genetic inheritance of color blindness, the prevalence of color blindness, DNA cleavage by restriction nucleases, X chromosome inactivation testing, the X Inactivation Center, and the consequences of XIC mutations on X inactivation.

Instructor

Romain Zufferey

Official source

Related concepts (32)

XIST

Xist (X-inactive specific transcript) is a non-coding RNA on the X chromosome of the placental mammals that acts as a major effector of the X-inactivation process. It is a component of the Xic – X-chromosome inactivation centre – along with two other RNA genes (Jpx and Ftx) and two protein genes (Tsx and Cnbp2). The Xist RNA, a large (17 kb in humans) transcript, is expressed on the inactive chromosome and not on the active one. It is processed in a similar way to mRNAs, through splicing and polyadenylation.

X-inactivation

X-inactivation (also called Lyonization, after English geneticist Mary Lyon) is a process by which one of the copies of the X chromosome is inactivated in therian female mammals. The inactive X chromosome is silenced by being packaged into a transcriptionally inactive structure called heterochromatin. As nearly all female mammals have two X chromosomes, X-inactivation prevents them from having twice as many X chromosome gene products as males, who only possess a single copy of the X chromosome (see dosage compensation).

Software testing

Software testing is the act of examining the artifacts and the behavior of the software under test by validation and verification. Software testing can also provide an objective, independent view of the software to allow the business to appreciate and understand the risks of software implementation. Test techniques include, but are not necessarily limited to: analyzing the product requirements for completeness and correctness in various contexts like industry perspective, business perspective, feasibility and viability of implementation, usability, performance, security, infrastructure considerations, etc.

Acceptance testing

In engineering and its various subdisciplines, acceptance testing is a test conducted to determine if the requirements of a specification or contract are met. It may involve chemical tests, physical tests, or performance tests. In systems engineering, it may involve black-box testing performed on a system (for example: a piece of software, lots of manufactured mechanical parts, or batches of chemical products) prior to its delivery.

Y chromosome

The Y chromosome is one of two sex chromosomes in therian mammals and other organisms. The other sex chromosome is the X chromosome. Y is normally the sex-determining chromosome in many species, since it is the presence or absence of Y that determines the male or female sex of offspring produced in sexual reproduction. In mammals, the Y chromosome contains the gene SRY, which triggers male development. The DNA in the human Y chromosome is composed of about 62 million base pairs, making it similar in size to chromosome 19.

Related lectures (29)

Genetic Expression and Chromosome Dosage

Explores genetic expression, chromosome characteristics, X chromosome inactivation, and DNA methylation impact.

Genetics: Chromosome Inheritance

Covers the basics of genetics, inheritance of alleles, genotype-phenotype relationship, and population genetics.

DNA Methylation and X Chromosome Inactivation

Explains DNA methylation, X chromosome inactivation, and mutation implications.

Chromosomal Sex Determination

Explores chromosomal sex determination, dosage compensation, X chromosome inactivation, and genetic traits influenced by sex chromosomes.

Neuroepigenetics: Molecular Mechanisms and Cognitive Implications