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This lecture covers the principles of radiation detection, focusing on semiconductor materials, such as high-purity Germanium detectors, and their operation at low temperatures. It also discusses systems like hybrid photodiodes, photomultiplier tubes, photodiodes, silicon photomultipliers, and avalanche photodiodes, highlighting their characteristics, advantages, and applications. The lecture further explores the measurement chain in radiation counting, different types of detectors, energy resolution, counting statistics, uncertainties, and the Fano factor. It concludes with a comparison between various detector types, emphasizing the superior resolution power of semiconductors over other materials.