Lecture

Introduction to simulation of networks

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Description

This lecture introduces the simulation of networks, focusing on the various ways to model pieces of the brain at different spatial scales, from meters to nanometers, and the tools and platforms used for simulating brain models, such as NEURON, Topographica, and NEST. It also covers the NEURON Simulation Environment, a domain-specific simulator for conducting neuron and network simulations, with Python support and high performance capabilities. The lecture delves into research using simulation, showcasing over 2300 publications utilizing NEURON for multi-scale models of brain structures.

In MOOC

Simulating a hippocampus micro-circuit

Official source

Related concepts (32)

Brain

A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a vertebrate's body. In a human, the cerebral cortex contains approximately 14–16 billion neurons, and the estimated number of neurons in the cerebellum is 55–70 billion. Each neuron is connected by synapses to several thousand other neurons.

Chromosome

A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are the histones. These proteins, aided by chaperone proteins, bind to and condense the DNA molecule to maintain its integrity. These chromosomes display a complex three-dimensional structure, which plays a significant role in transcriptional regulation.

Y chromosome

The Y chromosome is one of two sex chromosomes in therian mammals and other organisms. The other sex chromosome is the X chromosome. Y is normally the sex-determining chromosome in many species, since it is the presence or absence of Y that determines the male or female sex of offspring produced in sexual reproduction. In mammals, the Y chromosome contains the gene SRY, which triggers male development. The DNA in the human Y chromosome is composed of about 62 million base pairs, making it similar in size to chromosome 19.

X chromosome

The X chromosome is one of the two sex chromosomes in many organisms, including mammals, and is found in both males and females. It is a part of the XY sex-determination system and XO sex-determination system. The X chromosome was named for its unique properties by early researchers, which resulted in the naming of its counterpart Y chromosome, for the next letter in the alphabet, following its subsequent discovery. It was first noted that the X chromosome was special in 1890 by Hermann Henking in Leipzig.

Brain simulation

Brain simulation is the concept of creating a functioning computer model of a brain or part of a brain. Brain simulation projects intend to contribute to a complete understanding of the brain, and eventually also assist the process of treating and diagnosing brain diseases. Various simulations from around the world have been fully or partially released as open source software, such as C. elegans, and the Blue Brain Project Showcase.

Related lectures (64)

Scientific Computing in Neuroscience

Explores the history and tools of scientific computing in neuroscience, emphasizing the simulation of neurons and networks.

Brain Simulation Platform: SimUI Tutorial MOOC: Simulating a hippocampus micro-circuit

Covers a tutorial on simulating a hippocampus microcircuit using the user-friendly SimUI.

Genetic Distance Calculation

Explores genetic distance calculation, sequence alignment, and the impact of friction.

Genetics: Chromosome Inheritance

Covers the basics of genetics, inheritance of alleles, genotype-phenotype relationship, and population genetics.

Why study human neuronal microcircuits