Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Lecture

Extracellular Matrix: Structure and Function

Description

This lecture delves into the intricate world of the extracellular matrix, focusing on its two fundamental types: interstitial and basement membrane. The discussion covers the composition, function, and significance of these matrices, highlighting the role of proteins like collagen and elastin. The synthesis process, modifications, and assembly of collagen fibers are explored in detail, shedding light on the importance of proper organization for tissue stability. The lecture also touches upon diseases related to collagen, emphasizing the critical role of enzymes in collagen synthesis. Through a comprehensive analysis of the extracellular matrix components, this lecture provides a deep understanding of the structural framework that supports various tissues in the human body.

This video is available exclusively on Mediaspace for a restricted audience. Please log in to MediaSpace to access it if you have the necessary permissions.

Watch on Mediaspace

Instructors (2)

Maartje Martina Cornelia Bastings

Romain Zufferey

Official source

Related concepts (27)

Extracellular matrix

In biology, the extracellular matrix (ECM), also called intercellular matrix, is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.

Collagen

Collagen (ˈkɒlədʒən) is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content. Collagen consists of amino acids bound together to form a triple helix of elongated fibril known as a collagen helix. It is mostly found in connective tissue such as cartilage, bones, tendons, ligaments, and skin.

Matrix multiplication

In mathematics, particularly in linear algebra, matrix multiplication is a binary operation that produces a matrix from two matrices. For matrix multiplication, the number of columns in the first matrix must be equal to the number of rows in the second matrix. The resulting matrix, known as the matrix product, has the number of rows of the first and the number of columns of the second matrix. The product of matrices A and B is denoted as AB.

Extracellular fluid

In cell biology, extracellular fluid (ECF) denotes all body fluid outside the cells of any multicellular organism. Total body water in healthy adults is about 60% (range 45 to 75%) of total body weight; women and the obese typically have a lower percentage than lean men. Extracellular fluid makes up about one-third of body fluid, the remaining two-thirds is intracellular fluid within cells. The main component of the extracellular fluid is the interstitial fluid that surrounds cells.

Elastic fiber

Elastic fibers (or yellow fibers) are an essential component of the extracellular matrix composed of bundles of proteins (elastin) which are produced by a number of different cell types including fibroblasts, endothelial, smooth muscle, and airway epithelial cells. These fibers are able to stretch many times their length, and snap back to their original length when relaxed without loss of energy. Elastic fibers include elastin, elaunin and oxytalan.

Related lectures (31)

Macro-materials for Tissue Engineering

Covers the use of macro-materials in tissue engineering, including key components, scaffold classification, bioresorbable polymers, and hydrogel applications.

Discrete Symmetries: Asymptotic States and S-matrix

Covers the concept of discrete symmetries, focusing on the introduction to asymptotic states and S-matrix.

Linear Algebra: Matrices Properties

Explores properties of 3x3 matrices with real coefficients and determinant calculation methods.

Asymptotic States and S-matrix

Covers the concept of asymptotic states and S-matrix in quantum field theory, focusing on the evolution of wave packets and the scattering states.

Asymptotic States and S-matrix: Operators