Lecture

Extracellular Matrix and Cell Communication

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In course

MSE-212: Biology for engineers

Le cours est une introduction aux sciences de la vie en tant que domaine pluridisciplinaire ayant de multiples connexions avec l'ingénierie des matériaux. Il permettra aux étudiants de trouver dans la biologie une inspiration lors des leur activités dans l ...

Description

This lecture covers the structure and function of the extracellular matrix (ECM), including collagen, fibronectin, laminin, and proteoglycan. It explores integrins as key receptors connecting cells to the ECM, and the role of ECM in cell adhesion, migration, and survival. The presentation delves into the organization of epithelial cells, basement membrane components, and the critical role of laminin in cell differentiation and adhesion. Additionally, it discusses the impact of ECM-mimicking biomaterials on cell behavior and the dynamic reciprocity between cells and their surroundings. The lecture concludes with insights into bacterial systems, biofilms, and the brain-gut connection.

Instructors (2)

Romain Zufferey

Teaching & PhD Courses Biology for engineers MSE-212 This course consists of an introduction to biology and more particularly to biology as a multidisciplinary field, emphasizing natural examples of materials engineering. It should therefore allow engineering students to find inspiration from biology in future materials research problems. Cellular biology and biochemistry for engineers BIO-105 Basic course in biochemistry as well as cellular and molecular biology for non-life

Maartje Martina Cornelia Bastings

Expertise Can we use structural material properties on the nanoscale to engineer selective interactions at the bio-interface?The goal of the Programmable Biomaterials Lab is to understand the molecular design rules behind selective multivalent interactions at the bio-interface. We use DNA as engineering tool to explore the importance of structural mechanics and precise control of valency and patterns on directional interactions and self-assembly. Expertise Can we use structural material properties on the na

Official source

Ontological neighbourhood

Biology

Cell biology: Healing

Related concepts (32)

Fibronectin

Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. It is approved for marketing as a topical solution in India by Central Drugs Standard Control organization in 2020 under the brand name FIBREGA for chronic wounds. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).

Extracellular polymeric substance

Extracellular polymeric substances (EPSs) are natural polymers of high molecular weight secreted by microorganisms into their environment. EPSs establish the functional and structural integrity of biofilms, and are considered the fundamental component that determines the physicochemical properties of a biofilm. EPS in the matrix of biofilms provides compositional support and protection of microbial communities from the harsh environments. Components of EPS can be of different classes of polysaccharides, lipids, nucleic acids, proteins, lipopolysaccharides, and minerals.

Laminin

Laminins are a family of glycoproteins of the extracellular matrix of all animals. They are major components of the basal lamina (one of the layers of the basement membrane), the protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. Laminins are heterotrimeric proteins with a high molecular mass (~400 to ~900 kDa).

Cell adhesion

Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released by cells into spaces between them. Cells adhesion occurs from the interactions between cell-adhesion molecules (CAMs), transmembrane proteins located on the cell surface.

Basement membrane

The basement membrane, also known as base membrane is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling. The basement membrane sits between epithelial tissues including mesothelium and endothelium, and the underlying connective tissue. As seen with the electron microscope, the basement membrane is composed of two layers, the basal lamina and the reticular lamina.

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