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This lecture delves into datacenter-scale software systems, covering how software is built and deployed, fundamental challenges, and recent research topics. It explores the challenges of datacenter-scale software, the importance of microservices in software architecture, and the evolution of an online service using Netflix as an example. The lecture discusses issues related to scaling, deployment, and performance optimization, emphasizing the significance of team collaboration and specialization. It also addresses the complexities of tail latency in online services, the impact of load balancing in microservices, and the role of the RPC layer in data manipulation and control transfer. The lecture concludes by exploring future trends in cloud computing, including serverless computing and open research topics.