Lecture

Drug Delivery and Targeting

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In course

MSE-471: Biomaterials (pour MX)

The course introduces the main classes of biomaterials used in the biomedical field. The interactions with biological environment are discussed and challenges highlighted. State of the art examples per type of material are discussed. Students will engineer ...

Description

This lecture delves into biomaterials for drug delivery, covering naturally derived and manmade biomaterials, polymers, nanoparticles, surfaces, materials for cell adhesion, immune engineering, and tissue engineering. It explains the importance of targeting in drug delivery, the challenges faced, and strategies to improve nanoparticle therapeutics through specific and selective targeting. The lecture also discusses passive vs active targeting, the role of ligands and receptors, and the use of multivalency in targeting. Various ligand-receptor pairs and receptor types are explored, along with the concepts of binding strength and multivalency theory. Examples of antigen-B cell binding and the use of multivalency in targeting are presented.

Instructor

Maartje Martina Cornelia Bastings

Expertise Can we use structural material properties on the nanoscale to engineer selective interactions at the bio-interface?The goal of the Programmable Biomaterials Lab is to understand the molecular design rules behind selective multivalent interactions at the bio-interface. We use DNA as engineering tool to explore the importance of structural mechanics and precise control of valency and patterns on directional interactions and self-assembly. Expertise Can we use structural material properties on the na

Official source

Related concepts (15)

Nanoparticle

A nanoparticle or ultrafine particle is usually defined as a particle of matter that is between 1 and 100 nanometres (nm) in diameter. The term is sometimes used for larger particles, up to 500 nm, or fibers and tubes that are less than 100 nm in only two directions. At the lowest range, metal particles smaller than 1 nm are usually called atom clusters instead.

Silver nanoparticle

Silver nanoparticles are nanoparticles of silver of between 1 nm and 100 nm in size. While frequently described as being 'silver' some are composed of a large percentage of silver oxide due to their large ratio of surface to bulk silver atoms. Numerous shapes of nanoparticles can be constructed depending on the application at hand. Commonly used silver nanoparticles are spherical, but diamond, octagonal, and thin sheets are also common. Their extremely large surface area permits the coordination of a vast number of ligands.

Cell adhesion

Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released by cells into spaces between them. Cells adhesion occurs from the interactions between cell-adhesion molecules (CAMs), transmembrane proteins located on the cell surface.

Molecular engineering

Molecular engineering is an emerging field of study concerned with the design and testing of molecular properties, behavior and interactions in order to assemble better materials, systems, and processes for specific functions. This approach, in which observable properties of a macroscopic system are influenced by direct alteration of a molecular structure, falls into the broader category of “bottom-up” design.

Cell adhesion molecule

Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular matrix (ECM), in a process called cell adhesion. In essence, CAMs help cells stick to each other and to their surroundings. CAMs are crucial components in maintaining tissue structure and function. In fully developed animals, these molecules play an integral role in generating force and movement and consequently ensuring that organs are able to execute their functions normally.

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Materials for Biomaterials: Overview & Applications

Series covers the fundamentals of biomaterials and their applications in various fields.

Extracellular Matrix and Cell Communication

Explores the extracellular matrix, cell-ECM interactions, and bacterial systems.

Polymers and Particles in Biomaterials

Explores the use of polymers, hydrogels, and particles in various biomaterials applications, covering topics such as drug delivery, cell adhesion, and tissue engineering.

Multivalency: Enhancing Local Concentration in Drug Targeting

Covers multivalency's role in enhancing local concentration for effective drug targeting and binding interactions.

Ligand-Receptor Interactions: Mechanisms and Quantification