Lecture

Structured Synaptic Connectivity in Hippocampal Regions

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In course

BIOENG-450: In silico neuroscience

"In silico Neuroscience" introduces students to a synthesis of modern neuroscience and state-of-the-art data management, modelling and computing technologies. ...

Description

This lecture delves into the intricate world of synaptic connectivity within the hippocampal regions, exploring the experimental validation of motif spatial embedding and the impact of morphology on cortical cell types. Through techniques like multi-patch clamp recordings and mGRASP, the instructor showcases the complexity of neuronal networks and the challenges in reconstructing connectivity at multiple scales. The lecture also highlights the significance of modeling approaches in understanding the connectome's complexity and the interplay between experiments and models.

Instructors (2)

Felix Schürmann

Felix Schürmann is co-director of the Blue Brain Project and involved in several research challenges of the European Human Brain Project. He studied physics at the University of Heidelberg, Germany, supported by the German National Academic Foundation. Later, as a Fulbright Scholar, he obtained his Master's degree (M.S.) in Physics from the State University of New York, Buffalo, USA, under the supervision of Richard Gonsalves. During these studies, he became curious about the role of different computing substrates and dedicated his master thesis to the simulation of quantum computing. He studied for his Ph.D. at the University of Heidelberg, Germany, under the supervision of Karlheinz Meier. For his thesis he co-designed an efficient implementation of a neural network in hardware.

Armando Romani

Official source

Ontological neighbourhood

Biology

Cell biology: Neurotransmission

Related concepts (32)

Romani people

The Romani, also spelled Romany or Rromani (ˈroʊməni or ˈrɒməni ), colloquially known as the Roma (: Rom), are an Indo-Aryan ethnic group who traditionally lived a nomadic, itinerant lifestyle. Linguistic and genetic evidence suggests that the Romani originated in the Indian subcontinent; in particular, the region of present-day Rajasthan. Their subsequent westward migration, possibly in waves, is now believed by historians to have occurred around 1000 CE.

Romani diaspora

The Romani people have several distinct populations, the largest being the Roma and the Calé, who reached Anatolia and the Balkans in the early 12th century, from a migration out of the Indian subcontinent beginning about 1st century – 2nd century AD. They settled in the areas of present-day Turkey, Greece, Serbia, Romania, Croatia, Moldova, Bulgaria, North Macedonia, Hungary, Albania, Kosovo, Bosnia and Herzegovina, Czech Republic, Slovenia and Slovakia, by order of volume, and Spain.

History of the Romani people

The Romani people, also referred to as Roma, Sinti or Kale, depending on the sub-group, are an Indo-Aryan ethnic group which primarily lives in Europe. The Romani may have migrated from what is the modern Indian state of Rajasthan, migrating to the northwest (the Punjab region of the Indian subcontinent) around 250 BCE. Their subsequent westward migration, possibly in waves, is now believed to have occurred beginning in about 500 CE. It has also been suggested that emigration from India may have taken place in the context of the raids by Mahmud of Ghazni.

Romani society and culture

The Romani people are a distinct ethnic and cultural group of peoples living all across the globe, who share a family of languages and sometimes a traditional nomadic mode of life. Though their exact origins are unclear, central India is a notable point of origin. Their language shares a common origin with, and is similar to, modern-day Gujarati and Rajasthani, borrowing loan words from other languages as they migrated from India. In Europe, even though their culture has been victimized by other cultures, they have still found a way to maintain their heritage and society.

Connectomics

Connectomics is the production and study of connectomes: comprehensive maps of connections within an organism's nervous system. More generally, it can be thought of as the study of neuronal wiring diagrams with a focus on how structural connectivity, individual synapses, cellular morphology, and cellular ultrastructure contribute to the make up of a network. The nervous system is a network made of billions of connections and these connections are responsible for our thoughts, emotions, actions, memories, function and dysfunction.

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