Lecture

Network Simulation and Activity Dynamics

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In course

NX-450: Computational neurosciences: biophysics

The course introduces students to a synthesis of modern neuroscience and state-of-the-art data management, modelling and computing technologies with a focus on the biophysical level. ...

Description

This lecture covers the simulation of neural networks, including the diverse components such as ion channels, morphologies, and synapses. It explores spontaneous and evoked network activity, in-vitro and in-vivo simulations, and the importance of replicating experimental conditions. The lecture delves into the challenges of studying network dynamics, the impact of different parameters, and the necessity of sensitivity analysis. It also discusses the reasons for simulating networks, the setup of simulations, and the validation process to ensure accurate predictions.

Instructors (2)

Armando Romani

Felix Schürmann

Felix Schürmann is co-director of the Blue Brain Project and involved in several research challenges of the European Human Brain Project. He studied physics at the University of Heidelberg, Germany, supported by the German National Academic Foundation. Later, as a Fulbright Scholar, he obtained his Master's degree (M.S.) in Physics from the State University of New York, Buffalo, USA, under the supervision of Richard Gonsalves. During these studies, he became curious about the role of different computing substrates and dedicated his master thesis to the simulation of quantum computing. He studied for his Ph.D. at the University of Heidelberg, Germany, under the supervision of Karlheinz Meier. For his thesis he co-designed an efficient implementation of a neural network in hardware.

Official source

Ontological neighbourhood

Biology

Cell biology: Neurotransmission

Related concepts (32)

Romani people

The Romani, also spelled Romany or Rromani (ˈroʊməni or ˈrɒməni ), colloquially known as the Roma (: Rom), are an Indo-Aryan ethnic group who traditionally lived a nomadic, itinerant lifestyle. Linguistic and genetic evidence suggests that the Romani originated in the Indian subcontinent; in particular, the region of present-day Rajasthan. Their subsequent westward migration, possibly in waves, is now believed by historians to have occurred around 1000 CE.

Romani language

Romani (ˈrɒməni,_ˈroʊ-; also Romany, Romanes ˈrɒmənɪs, Roma; rromani ćhib) is an Indo-Aryan macrolanguage of the Romani communities. According to Ethnologue, seven varieties of Romani are divergent enough to be considered languages of their own. The largest of these are Vlax Romani (about 500,000 speakers), Balkan Romani (600,000), and Sinte Romani (300,000). Some Romani communities speak mixed languages based on the surrounding language with retained Romani-derived vocabulary – these are known by linguists as Para-Romani varieties, rather than dialects of the Romani language itself.

Romani Holocaust

The Romani Holocaust or the Romani genocide—also known as the Porajmos (Romani pronunciation: phoɽajˈmos, meaning "the Devouring"), the Pharrajimos (meaning "the Cutting up", "the Fragmentation", "the Destruction"), and the Samudaripen ("Mass killing")—was the planned effort by Nazi Germany and its World War II allies and collaborators to commit ethnic cleansing and eventually genocide against European Roma and Sinti peoples during the Holocaust era.

History of the Romani people

The Romani people, also referred to as Roma, Sinti or Kale, depending on the sub-group, are an Indo-Aryan ethnic group which primarily lives in Europe. The Romani may have migrated from what is the modern Indian state of Rajasthan, migrating to the northwest (the Punjab region of the Indian subcontinent) around 250 BCE. Their subsequent westward migration, possibly in waves, is now believed to have occurred beginning in about 500 CE. It has also been suggested that emigration from India may have taken place in the context of the raids by Mahmud of Ghazni.

Synapse

In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target effector cell. Synapses are essential to the transmission of nervous impulses from one neuron to another. Neurons are specialized to pass signals to individual target cells, and synapses are the means by which they do so. At a synapse, the plasma membrane of the signal-passing neuron (the presynaptic neuron) comes into close apposition with the membrane of the target (postsynaptic) cell.

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Network Simulation: Spontaneous Activity and Validation

Covers spontaneous brain network activity, neural simulation, and validation, emphasizing the importance of in-vitro and in-vivo conditions for accurate network modeling.

Synaptic Transmission: Electrical vs Chemical

Compares electrical and chemical synapses, emphasizing their properties and behavior, including the neuromuscular junction and synapses in the CNS.

In Silico Neuroscience: Network Simulation

Delves into simulating network dynamics in in silico neuroscience, covering spontaneous and evoked activity, in-vitro and in-vivo simulations, and sensitivity analysis.

In Silico Neuroscience: Ion Channels and Neuronal Models

Explores detailed modeling of ion channels and neuronal morphologies in in silico neuroscience, covering neuron classification, ion channel kinetics, and experimental observations.

Scientific Computing in Neuroscience