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This lecture explores the intersection of genomics, health, and society, focusing on the impact of the Human Genome Project and the emergence of post-genomic perspectives. It delves into the ethical, legal, and social implications of genomic research, emphasizing the role of Science and Technology Studies in understanding the complex relationships between scientific knowledge, technology development, and societal dynamics. The lecture also addresses key questions from STS, such as the influence of science on society, the evolving nature of scientific objects, and the societal implications of scientific discoveries. Furthermore, it discusses the challenges and possibilities of personalized medicine, the role of epigenetics in health outcomes, and the importance of considering socio-environmental factors in genomic research.