Lecture

Inhibitors: NaTrpt

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In courses (2)

BIO-378: Physiology lab I

Le TP de physiologie introduit les approches expérimentales du domaine biomédical, avec les montages de mesure, les capteurs, le conditionnement des signaux, l'acquisition et traitement de données. Les résultats physiologiques finaux illustrent le contenu ...

BIO-379: Physiology lab II

Description

This lecture demonstrates the effects of inhibiting sodium transport by using an inhibitor called milorite, which acts rapidly but is highly toxic. The process of removing the inhibitor and observing the sodium transport recovery is also explored, showing a slow and challenging diffusion process. Additionally, the potential risks and difficulties of inhibiting NACTPase, which could lead to cell death and impact other physiological mechanisms, are discussed.

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Instructor

André Pexieder

Teaching & PhD Courses Physiology lab I BIO-378 The physiology laboratory introduce the experimental methods in the biomedical field, including experimental set-ups, transducers, signal conditioning, data acquisition and processing.The physiological end results illustrate the contents of the Physiologie par systèmes course. Physiology lab II BIO-379 The physiology laboratory introduce the experimental methods in the biomedical field, including experimental set-ups, transducer

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Related concepts (13)

Active transport

In cellular biology, active transport is the movement of molecules or ions across a cell membrane from a region of lower concentration to a region of higher concentration—against the concentration gradient. Active transport requires cellular energy to achieve this movement. There are two types of active transport: primary active transport that uses adenosine triphosphate (ATP), and secondary active transport that uses an electrochemical gradient.

Sodium–potassium pump

The sodium–potassium pump (sodium–potassium adenosine triphosphatase, also known as Na+/K+-ATPase, Na+/K+ pump, or sodium–potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na+/K+-ATPase enzyme is active (i.e. it uses energy from ATP). For every ATP molecule that the pump uses, three sodium ions are exported and two potassium ions are imported. Thus, there is a net export of a single positive charge per pump cycle.

Sodium

Sodium is a chemical element with the symbol Na (from Latin natrium) and atomic number 11. It is a soft, silvery-white, highly reactive metal. Sodium is an alkali metal, being in group 1 of the periodic table. Its only stable isotope is 23Na. The free metal does not occur in nature and must be prepared from compounds. Sodium is the sixth most abundant element in the Earth's crust and exists in numerous minerals such as feldspars, sodalite, and halite (NaCl).

Sodium channel

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily of cation channels. They are classified into 2 types: In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. These channels go through three different states called resting, active and inactive states.

Diffusion

Diffusion is the net movement of anything (for example, atoms, ions, molecules, energy) generally from a region of higher concentration to a region of lower concentration. Diffusion is driven by a gradient in Gibbs free energy or chemical potential. It is possible to diffuse "uphill" from a region of lower concentration to a region of higher concentration, like in spinodal decomposition. Diffusion is a stochastic process due to the inherent randomness of the diffusing entity and can be used to model many real-life stochastic scenarios.

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