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This lecture introduces the fundamentals of mechanism design, distinguishing between machines, mechanisms, and structures. Using a bicycle as an example, it explains how different components work together to create a complex machine. The lecture covers topics such as transmission mechanisms, derailleur systems, braking mechanisms, and bearing systems. It also delves into the theoretical and technical foundations necessary for embarking on a design project. The course is divided into two main blocks, with the first focusing on structural aspects and the second on mechanism design principles in the context of micro-technology.