Response surface methodologyIn statistics, response surface methodology (RSM) explores the relationships between several explanatory variables and one or more response variables. The method was introduced by George E. P. Box and K. B. Wilson in 1951. The main idea of RSM is to use a sequence of designed experiments to obtain an optimal response. Box and Wilson suggest using a second-degree polynomial model to do this. They acknowledge that this model is only an approximation, but they use it because such a model is easy to estimate and apply, even when little is known about the process.
Optimal designIn the design of experiments, optimal designs (or optimum designs) are a class of experimental designs that are optimal with respect to some statistical criterion. The creation of this field of statistics has been credited to Danish statistician Kirstine Smith. In the design of experiments for estimating statistical models, optimal designs allow parameters to be estimated without bias and with minimum variance. A non-optimal design requires a greater number of experimental runs to estimate the parameters with the same precision as an optimal design.
Design of experimentsThe design of experiments (DOE or DOX), also known as experiment design or experimental design, is the design of any task that aims to describe and explain the variation of information under conditions that are hypothesized to reflect the variation. The term is generally associated with experiments in which the design introduces conditions that directly affect the variation, but may also refer to the design of quasi-experiments, in which natural conditions that influence the variation are selected for observation.
Factorial experimentIn statistics, a full factorial experiment is an experiment whose design consists of two or more factors, each with discrete possible values or "levels", and whose experimental units take on all possible combinations of these levels across all such factors. A full factorial design may also be called a fully crossed design. Such an experiment allows the investigator to study the effect of each factor on the response variable, as well as the effects of interactions between factors on the response variable.
Fractional factorial designIn statistics, fractional factorial designs are experimental designs consisting of a carefully chosen subset (fraction) of the experimental runs of a full factorial design. The subset is chosen so as to exploit the sparsity-of-effects principle to expose information about the most important features of the problem studied, while using a fraction of the effort of a full factorial design in terms of experimental runs and resources.
Central composite designIn statistics, a central composite design is an experimental design, useful in response surface methodology, for building a second order (quadratic) model for the response variable without needing to use a complete three-level factorial experiment. After the designed experiment is performed, linear regression is used, sometimes iteratively, to obtain results. Coded variables are often used when constructing this design.
Mathematical optimizationMathematical optimization (alternatively spelled optimisation) or mathematical programming is the selection of a best element, with regard to some criterion, from some set of available alternatives. It is generally divided into two subfields: discrete optimization and continuous optimization. Optimization problems arise in all quantitative disciplines from computer science and engineering to operations research and economics, and the development of solution methods has been of interest in mathematics for centuries.
Combinatorial optimizationCombinatorial optimization is a subfield of mathematical optimization that consists of finding an optimal object from a finite set of objects, where the set of feasible solutions is discrete or can be reduced to a discrete set. Typical combinatorial optimization problems are the travelling salesman problem ("TSP"), the minimum spanning tree problem ("MST"), and the knapsack problem. In many such problems, such as the ones previously mentioned, exhaustive search is not tractable, and so specialized algorithms that quickly rule out large parts of the search space or approximation algorithms must be resorted to instead.
Convex optimizationConvex optimization is a subfield of mathematical optimization that studies the problem of minimizing convex functions over convex sets (or, equivalently, maximizing concave functions over convex sets). Many classes of convex optimization problems admit polynomial-time algorithms, whereas mathematical optimization is in general NP-hard.
Immune responseAn immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body. In addition, there are other forms of immune response.
Earth ellipsoidAn Earth ellipsoid or Earth spheroid is a mathematical figure approximating the Earth's form, used as a reference frame for computations in geodesy, astronomy, and the geosciences. Various different ellipsoids have been used as approximations. It is a spheroid (an ellipsoid of revolution) whose minor axis (shorter diameter), which connects the geographical North Pole and South Pole, is approximately aligned with the Earth's axis of rotation.
Geodesics on an ellipsoidThe study of geodesics on an ellipsoid arose in connection with geodesy specifically with the solution of triangulation networks. The figure of the Earth is well approximated by an oblate ellipsoid, a slightly flattened sphere. A geodesic is the shortest path between two points on a curved surface, analogous to a straight line on a plane surface. The solution of a triangulation network on an ellipsoid is therefore a set of exercises in spheroidal trigonometry .
Hayford ellipsoidThe Hayford ellipsoid is a geodetic reference ellipsoid, named after the US geodesist John Fillmore Hayford (1868–1925), which was introduced in 1910. The Hayford ellipsoid was also referred to as the International ellipsoid 1924 after it had been adopted by the International Union of Geodesy and Geophysics IUGG in 1924, and was recommended for use all over the world. Many countries retained their previous ellipsoids. The Hayford ellipsoid is defined by its semi-major axis a = 6378388.000m and its flattening f = 1:297.
Bessel ellipsoidThe Bessel ellipsoid (or Bessel 1841) is an important reference ellipsoid of geodesy. It is currently used by several countries for their national geodetic surveys, but will be replaced in the next decades by modern ellipsoids of satellite geodesy. The Bessel ellipsoid was derived in 1841 by Friedrich Wilhelm Bessel, based on several arc measurements and other data of continental geodetic networks of Europe, Russia and the British Survey of India.
EllipsoidAn ellipsoid is a surface that can be obtained from a sphere by deforming it by means of directional scalings, or more generally, of an affine transformation. An ellipsoid is a quadric surface; that is, a surface that may be defined as the zero set of a polynomial of degree two in three variables. Among quadric surfaces, an ellipsoid is characterized by either of the two following properties. Every planar cross section is either an ellipse, or is empty, or is reduced to a single point (this explains the name, meaning "ellipse-like").
Eigenvalues and eigenvectorsIn linear algebra, an eigenvector (ˈaɪgənˌvɛktər) or characteristic vector of a linear transformation is a nonzero vector that changes at most by a constant factor when that linear transformation is applied to it. The corresponding eigenvalue, often represented by , is the multiplying factor. Geometrically, a transformation matrix rotates, stretches, or shears the vectors it acts upon. The eigenvectors for a linear transformation matrix are the set of vectors that are only stretched, with no rotation or shear.
Frequency responseIn signal processing and electronics, the frequency response of a system is the quantitative measure of the magnitude and phase of the output as a function of input frequency. The frequency response is widely used in the design and analysis of systems, such as audio and control systems, where they simplify mathematical analysis by converting governing differential equations into algebraic equations.
HyperboloidIn geometry, a hyperboloid of revolution, sometimes called a circular hyperboloid, is the surface generated by rotating a hyperbola around one of its principal axes. A hyperboloid is the surface obtained from a hyperboloid of revolution by deforming it by means of directional scalings, or more generally, of an affine transformation. A hyperboloid is a quadric surface, that is, a surface defined as the zero set of a polynomial of degree two in three variables.
PiThe number pi (paɪ; spelled out as "pi") is a mathematical constant that is the ratio of a circle's circumference to its diameter, approximately equal to 3.14159. The number pi appears in many formulae across mathematics and physics. It is an irrational number, meaning that it cannot be expressed exactly as a ratio of two integers, although fractions such as are commonly used to approximate it. Consequently, its decimal representation never ends, nor enters a permanently repeating pattern.
Quadratic formIn mathematics, a quadratic form is a polynomial with terms all of degree two ("form" is another name for a homogeneous polynomial). For example, is a quadratic form in the variables x and y. The coefficients usually belong to a fixed field K, such as the real or complex numbers, and one speaks of a quadratic form over K. If , and the quadratic form equals zero only when all variables are simultaneously zero, then it is a definite quadratic form; otherwise it is an isotropic quadratic form.
