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Delves into identifying drug targets, ensuring efficacy, and maintaining safety in medical chemistry, covering genetic tests, chirality, stereochemistry, drug resistance, and drug-likeness rules.
Explores molecular glues as new drug modalities, focusing on binding forces, energetics, biomolecular interactions, quantification, drug development, and structural characterization.
Covers posttranslational modifications, focusing on phosphorylation and protein phosphatases, and explains kinase specificity assays and the optimal phosphorylation consensus.
Explores drug targets, particularly nuclear receptors like PPARy and pregnane X receptor, and their impact on endocrine signaling and drug pharmacokinetics.
Explores the selection and rationale of preclinical animal models in drug development, emphasizing the 10 to 15-year path to a marketed small-molecule drug.
Explores the self-assembly of heterobimetallic systems to create robust duplexes in water, emphasizing the importance of synthetic H-bond systems for materials fabrication.
