Lectures related to Inhibitor Design & Analysis

Protein-Ligand Interactions: Importance and Affinity

Explores the importance of protein-ligand interactions, focusing on binding affinities and energetic landscapes, with implications for drug development and specificity.

Inhibitor Design & Analysis

Covers the fundamentals of inhibitor design and analysis, emphasizing the importance of targeting cysteine residues.

SEGREGATION of KINETIC REACTIVITY & BINDING AFFINITY

The paper focuses on the importance of reversible interactions to potency and mechanisms of drug resistance.

Interrogating Drugs' Mode of Action

Delves into enzyme inhibition, reversible and irreversible binding, and covalent drugs, exploring drug modes of action and their impact on drug efficacy.

Activity-based Protein Profiling: Druggable Sites Identification

Explores Activity-based Protein Profiling for druggable site identification and strategies to minimize off-target reactivity of covalent inhibitors.

Pharmacodynamics: Acid-sensing ion channels and Drug Targets

Explores acid-sensing ion channels, drug targets, and ligand-receptor binding.

Enzyme Drug Targets

Explores enzyme drug targets, tyrosine kinase inhibitors, vascular tone control, and viral life cycle interventions.

Enzymes: Catalytic Strategies

Explores enzyme catalytic strategies, including proteases and carbonic anhydrase, inhibition mechanisms, and specificity of serine proteases.

Pharmacological Targets and Interventions

Explores targets for drug action and the design of specific inhibitors.

Protein-Ligand Interactions

Explores the principles of protein-ligand interactions, covering methods for measuring affinity and kinetics in drug development.

Pharmacodynamics: Ligand-Receptor Interactions and Drug Effects

Explores ligand-receptor interactions, drug effects, modulation mechanisms, and factors influencing drug responses.

Chemical Biology meets Drug Discovery

Explores Chemical Biology, Drug Discovery, enzyme kinetics, and inhibition methods, including competitive and non-competitive inhibition.

Pharmacology: Drug Targets and Mechanisms

Discusses ligand-receptor binding, drug targets, insulin physiology, NSAIDs, and tyrosine kinase inhibitors.

Pharmacodynamics and Drug Targets

Explores pharmacodynamics, drug targets, the renin-angiotensin system, ACE inhibitors, diuretics, and exam questions.

Inclusion of Fermented Foods in Food Guides

Discusses the inclusion of fermented foods in global food guides, exploring their benefits and risks, enzyme kinetics, and the history of food enzymes.

Protein Phosphorylation: Mechanisms & Regulation

Explores protein phosphorylation, detailing common modifications like acetylation and ubiquitination, kinase specificity, and activation mechanisms.

Kinetics: Reaction Rates and Equilibrium

Explores reaction kinetics, rate laws, measurement techniques, and binding kinetics between ligands and proteins.

Protein Folding: Forces and Mechanisms

Explores protein folding forces, including van der Waals interactions, hydrogen bonds, and salt bridges, and their impact on stability.

Protein Reactivity and Chemical Probes

Explores protein reactivity, chemical probes, and quantitative chemoproteomics in biological systems.

Kinase Inhibitors: Types and Mechanisms Log in to Mediaspace to watch this video

Explores kinase inhibitors, their types, mechanisms, and experimental evaluation, emphasizing the significance of covalent drugs in modern pharmaceutical research.