Homotopy groupIn mathematics, homotopy groups are used in algebraic topology to classify topological spaces. The first and simplest homotopy group is the fundamental group, denoted which records information about loops in a space. Intuitively, homotopy groups record information about the basic shape, or holes, of a topological space. To define the n-th homotopy group, the base-point-preserving maps from an n-dimensional sphere (with base point) into a given space (with base point) are collected into equivalence classes, called homotopy classes.
Homotopy theoryIn mathematics, homotopy theory is a systematic study of situations in which maps can come with homotopies between them. It originated as a topic in algebraic topology but nowadays is studied as an independent discipline. Besides algebraic topology, the theory has also been used in other areas of mathematics such as algebraic geometry (e.g., A1 homotopy theory) and (specifically the study of ). In homotopy theory and algebraic topology, the word "space" denotes a topological space.
Homotopy fiberIn mathematics, especially homotopy theory, the homotopy fiber (sometimes called the mapping fiber) is part of a construction that associates a fibration to an arbitrary continuous function of topological spaces . It acts as a homotopy theoretic kernel of a mapping of topological spaces due to the fact it yields a long exact sequence of homotopy groupsMoreover, the homotopy fiber can be found in other contexts, such as homological algebra, where the distinguished trianglegives a long exact sequence analogous to the long exact sequence of homotopy groups.
Homotopy categoryIn mathematics, the homotopy category is a built from the category of topological spaces which in a sense identifies two spaces that have the same shape. The phrase is in fact used for two different (but related) categories, as discussed below. More generally, instead of starting with the category of topological spaces, one may start with any and define its associated homotopy category, with a construction introduced by Quillen in 1967. In this way, homotopy theory can be applied to many other categories in geometry and algebra.
HomotopyIn topology, a branch of mathematics, two continuous functions from one topological space to another are called homotopic (from ὁμός "same, similar" and τόπος "place") if one can be "continuously deformed" into the other, such a deformation being called a homotopy (həˈmɒtəpiː, ; ˈhoʊmoʊˌtoʊpiː, ) between the two functions. A notable use of homotopy is the definition of homotopy groups and cohomotopy groups, important invariants in algebraic topology. In practice, there are technical difficulties in using homotopies with certain spaces.
Homotopy groups of spheresIn the mathematical field of algebraic topology, the homotopy groups of spheres describe how spheres of various dimensions can wrap around each other. They are examples of topological invariants, which reflect, in algebraic terms, the structure of spheres viewed as topological spaces, forgetting about their precise geometry. Unlike homology groups, which are also topological invariants, the homotopy groups are surprisingly complex and difficult to compute.
Stable homotopy theoryIn mathematics, stable homotopy theory is the part of homotopy theory (and thus algebraic topology) concerned with all structure and phenomena that remain after sufficiently many applications of the suspension functor. A founding result was the Freudenthal suspension theorem, which states that given any pointed space , the homotopy groups stabilize for sufficiently large. In particular, the homotopy groups of spheres stabilize for . For example, In the two examples above all the maps between homotopy groups are applications of the suspension functor.
DNA repairDNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes.
Nucleotide excision repairNucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by specific glycosylases.
Finite differenceA finite difference is a mathematical expression of the form f (x + b) − f (x + a). If a finite difference is divided by b − a, one gets a difference quotient. The approximation of derivatives by finite differences plays a central role in finite difference methods for the numerical solution of differential equations, especially boundary value problems. The difference operator, commonly denoted is the operator that maps a function f to the function defined by A difference equation is a functional equation that involves the finite difference operator in the same way as a differential equation involves derivatives.
Finite difference methodIn numerical analysis, finite-difference methods (FDM) are a class of numerical techniques for solving differential equations by approximating derivatives with finite differences. Both the spatial domain and time interval (if applicable) are discretized, or broken into a finite number of steps, and the value of the solution at these discrete points is approximated by solving algebraic equations containing finite differences and values from nearby points.
Difference quotientIn single-variable calculus, the difference quotient is usually the name for the expression which when taken to the limit as h approaches 0 gives the derivative of the function f. The name of the expression stems from the fact that it is the quotient of the difference of values of the function by the difference of the corresponding values of its argument (the latter is (x + h) - x = h in this case). The difference quotient is a measure of the average rate of change of the function over an interval (in this case, an interval of length h).
