Lecture

DNA as Biomaterial Lecture: Programming with DNA Origami

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In course

BIOENG-460: Biomaterials and tissue engineering

This course covers the fundamental concepts of the design, function and application of state-of-the-art biomaterials, and an overview of how engineering approaches can be used to investigate and manipulate cell and tissue functions. ...

Description

This lecture covers the fundamentals of DNA, its structure, function, and properties, as well as DNA nano-engineering, bioengineering applications, and the use of DNA as a programmable biomaterial. Topics include DNA origami, synthesis, assembly, cell uptake, immune activation, and the engineering of various DNA structures. The lecture also explores the role of DNA in bioengineering, focusing on its potential in creating wireframe structures, lattice-based 3D origami, and more complex DNA particles. Additionally, it delves into the interaction of DNA with cells, discussing the challenges and strategies for delivering DNA-based materials into cells and the immune response. The lecture showcases the versatility of DNA as a biomaterial for various applications.

Instructors (2)

Li Tang

Education and Training Postdoctoral Fellow, Massachusetts Institute of Technology, 2013 - 2016 Ph.D., University of Illinois at Urbana-Champaign, 2007 - 2012 B.S., Peking University, 2003-2007

Diego Ghezzi

Prof. Diego Ghezzi holds the Medtronic Chair in Neuroengineering at the School of Engineering at the Ecole Polytechnique Fédérale de Lausanne. He received his M.Sc. in Biomedical Engineering (2004) and Ph.D. in Bioengineering (2008) from Politecnico di Milano. From 2008 to 2013, he completed his postdoctoral training at Istituto Italiano di Tecnologia in Genova at the Department of Neuroscience and Brain Technologies; where he was promoted to Researcher in 2013. In 2015, he was appointed as Tenure-Track Assistant Professor of Bioengineering at the EPFL Center for Neuroprosthetics and Institute of Bioengineering.

Official source

Related concepts (32)

DNA

Deoxyribonucleic acid (diːˈɒksᵻˌraɪboʊnjuːˌkliːᵻk,_-ˌkleɪ-; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of all known organisms and many viruses. DNA and ribonucleic acid (RNA) are nucleic acids. Alongside proteins, lipids and complex carbohydrates (polysaccharides), nucleic acids are one of the four major types of macromolecules that are essential for all known forms of life.

DNA polymerase

A DNA polymerase is a member of a family of enzymes that catalyze the synthesis of DNA molecules from nucleoside triphosphates, the molecular precursors of DNA. These enzymes are essential for DNA replication and usually work in groups to create two identical DNA duplexes from a single original DNA duplex. During this process, DNA polymerase "reads" the existing DNA strands to create two new strands that match the existing ones. These enzymes catalyze the chemical reaction deoxynucleoside triphosphate + DNAn pyrophosphate + DNAn+1.

DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes.

DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. DNA replication occurs in all living organisms acting as the most essential part of biological inheritance. This is essential for cell division during growth and repair of damaged tissues, while it also ensures that each of the new cells receives its own copy of the DNA. The cell possesses the distinctive property of division, which makes replication of DNA essential.

Field-programmable gate array

A field-programmable gate array (FPGA) is an integrated circuit designed to be configured after manufacturing. The FPGA configuration is generally specified using a hardware description language (HDL), similar to that used for an application-specific integrated circuit (ASIC). Circuit diagrams were previously used to specify the configuration, but this is increasingly rare due to the advent of electronic design automation tools. FPGAs contain an array of programmable logic blocks, and a hierarchy of reconfigurable interconnects allowing blocks to be wired together.

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Related concepts (32)

Field-programmable gate array