Lecture

Metabolism: Catabolism and Regulation

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In course

ENV-103: Biology

This course will cover the fundamental principles governing life and the living world. Topics will include the diversity of living organisms, cellular biology, genetics, evolution, and ecology. This course provides a foundation in biology, fostering critic ...

Description

This lecture covers the catabolic pathways of metabolism, focusing on glycolysis, pyruvate oxidation, the citric acid cycle, and oxidative phosphorylation. It also delves into the diversity of catabolic pathways, fermentation, and anabolic reactions. The instructor explains the role of ATP, electron transport chains, and chemiosmosis in energy production. Additionally, the lecture explores the regulation of metabolism, including transcriptional and translational control, sigma factors, and regulatory proteins. The importance of energy management, metabolic diversity, and the coordination of metabolic pathways within cells are emphasized.

Instructors (4)

Pierre Rossi

Expertise Molecular tools (from DNA/RNA extractions procedures to complex community analysis) dedicated to microbial ecology Bioremediation of contaminated habitatsBiorecycling of valuable and critical metals for electronic waste and bottom ashesMultivariate statistics and numerical ecology applied to the microbial ecology field (soils, bioreactors, etc)Water desinfection proceduresGroundwater tracing with bacteriophagesCharacterization of bacterial strains contaminating industrial processes and medical env

Anna Carratala Ripolles

During my PhD, I mainly focused on characterizing the effect of environmental factors (namely temperature and sunlight) and disinfectants on the stability of human viral pathogens as contaminants of aquatic environments. In addition,I developed a novel source tracking tool to identify avian fecal contamination in environmental samples. Thanks to a research fellowship given by the Spanish Ministry of Science and Technology, I also had the opportunity to explore the diversity of marine viruses in Mediterranean coastal waters by genetic fingerprinting and by next generation sequencing. Later on, I became interested in the long-term effect of environmental stressors on virus communities, so I joined the LCE as a postdoc to investigate the adaptation of enteroviruses to ultraviolet radiation. For 4 years, I worked on developing UV-resistant viruses and characterizing their acquired phenotypic and genetic properties by combining directed evolution experiments, deep sequencing and population genetics. Out of the lab, I am passionate about nature, traveling and scuba diving.

Ianina Altshuler

Teaching & PhD PhD Students Haohua He, Anna Dukat, Laureen Sarah Ahlers, Anastasiia Kosolapova, Grace Emma Marsh Courses Biology ENV-103 This course will cover the fundamental principles governing life and the living world. Topics will include the diversity of living organisms, cellular biology, genetics, evolution, and ecology. This course provides a foundation in biology, fostering critical thinking & analytical skills. EESS - CESS Seminar Course - option 1 (FALL) ENV-630(a)

Julien Maillard

2011 - present: Research associate at the Laboratory for Environmental Biotechnology (LBE, IIE-ENAC, EPFL) 2007 - 2010: Postdoctoral Fellow at the Laboratory for Environmental Biotechnology (LBE, IIE-ENAC, EPFL) 2005 - 2006: Postdoctoral Fellow at the University of East Anglia (UEA, Norwich, UK) 2000 - 2004: PhD thesis at the Laboratory for Environmental Biotechnology (LBE) 1995 - 2000: B.sc & M.sc at the Swiss Federal Institute for Technology, Zurich (ETHZ)

Official source

Ontological neighbourhood

Biology

Cell biology: Cell metabolism

Related concepts (32)

Cellular respiration

Cellular respiration is the process by which biological fuels are oxidised in the presence of an inorganic electron acceptor, such as oxygen, to drive the bulk production of adenosine triphosphate (ATP), which contains energy. Cellular respiration may be described as a set of metabolic reactions and processes that take place in the cells of organisms to convert chemical energy from nutrients into ATP, and then release waste products.

Carbohydrate metabolism

Carbohydrate metabolism is the whole of the biochemical processes responsible for the metabolic formation, breakdown, and interconversion of carbohydrates in living organisms. Carbohydrates are central to many essential metabolic pathways. Plants synthesize carbohydrates from carbon dioxide and water through photosynthesis, allowing them to store energy absorbed from sunlight internally. When animals and fungi consume plants, they use cellular respiration to break down these stored carbohydrates to make energy available to cells.

Metabolism

Metabolism (məˈtæbəlɪzəm, from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks for proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments.

Amphibolic

The term amphibolic (ἀμφίβολος) is used to describe a biochemical pathway that involves both catabolism and anabolism. Catabolism is a degradative phase of metabolism in which large molecules are converted into smaller and simpler molecules, which involves two types of reactions. First, hydrolysis reactions, in which catabolism is the breaking apart of molecules into smaller molecules to release energy. Examples of catabolic reactions are digestion and cellular respiration, where sugars and fats are broken down for energy.

Phosphorylation

In biochemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology. Protein phosphorylation often activates (or deactivates) many enzymes. Phosphorylation is essential to the processes of both anaerobic and aerobic respiration, which involve the production of adenosine triphosphate (ATP), the "high-energy" exchange medium in the cell.

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ATP Synthesis: Glycolysis and Krebs Cycle

Explores ATP synthesis through glycolysis, fermentation, oxidation pathways, and oxidative phosphorylation in mitochondria.

Metabolism: Energy and Cellular Compounds

Explores catabolism, anabolism, energy balance, ATP production, and cellular respiration processes.

Citric Acid Cycle: Overview

Provides an in-depth exploration of the citric acid cycle, focusing on Acetyl-CoA production, oxidation, and regulation, as well as the process of fatty acid oxidation and transport.

Microbial metabolism: Energy Generation and Biomass Production

Explores microbial metabolism, focusing on energy generation, biomass production, redox reactions, and electron carriers.

Methanogenesis and Methylotrophy: Pathways and Mechanisms