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This lecture covers the concept of synchronous modulation and demodulation, focusing on the impact of phase adjustments in amplification systems. It explains how a synchronous switch can introduce higher harmonics compared to a multiplier, and how digital lock-in amplifiers can perform demodulation in the digital domain. The lecture also discusses the use of optical barriers for passage sensors and the benefits of synchronous modulation in signal analysis. Examples include fluorescence measurements and resistive sensor applications, highlighting the importance of eliminating noise and offset drift in measurements.