Lecture

Polymer Collapse: Protein Folding and Interactions

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In course

PHYS-441: Statistical physics of biomacromolecules

Biological macromolecules such as DNA, RNA, proteins and cytoskeletal filaments are polymers. As such, they share a set of properties that are common to any polymer, which are the focus of this course. Details about the protein folding problem will be cove ...

Description

This lecture discusses the process of polymer collapse, focusing on protein folding and interactions. The instructor explains how hydrophobicity and other interactions drive the collapse to a compact state, emphasizing the hierarchical nature of protein folding. The lecture also delves into the meaning of the B₂ factor and the role of attractive interactions in polymer collapse. Various concepts such as the Flory approach, relevant interactions, and the impact of temperature on collapse are explored. The discussion extends to the necessity of monomers to avoid each other and the implications of attractive potentials in DNA-binding proteins.

Official source

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