Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Lecture

Tissue Mechanical Remodeling

In course

ME-482: Biomechanics of the musculoskeletal system

The basis for a mechanical description of the musculoskeletal system are presented. This description is based on the concepts of solid mechanics, physiology and anatomy of the musculoskeletal system. Concrete examples of the development of implants are als ...

Description

This lecture explores the biomechanics of the musculoskeletal system, focusing on bone remodeling at different time scales, from thousands of years to months. It delves into the mechanical and hormonal aspects of bone adaptation, the influence of mechanical stimulus on bone density evolution, and the differential effects of mechanical loading on bone remodeling. The instructor discusses how cells control bone structure during remodeling, the impact of mechanical demands on bone formation, and the mathematical formulation linking density evolution to mechanical stimulus. Clinical and animal studies are highlighted as essential to determine the parameters of bone evolution law.

This video is available exclusively on Mediaspace for a restricted audience. Please log in to MediaSpace to access it if you have the necessary permissions.

Watch on Mediaspace

Instructor

Dominique Pioletti

Dominique Pioletti received his Master in Physics from the Swiss Federal Institute of Technology Lausanne (EPFL) in 1992. He pursued his education in the same Institution and obtained his PhD in biomechanics in 1997. He developed original constitutive laws taking into account viscoelasticity in large deformations. Then he spent two years at UCSD as post-doc fellow acquiring know-how in cell and molecular biology. He was interested in particular to gene expression of bone cells in contact to orthopedic implant. In April 2006, Dominique Pioletti was appointed Assistant Professor tenure-track at the EPFL and is director of the Laboratory of Biomechanical Orthopedics. His research topics include biomechanics and tissue engineering of musculo-skeletal tissues; mechano-transduction in bone; development of orthopedic implant as drug delivery system. Since 2013, he has been promoted to the rank of Associate Professor.

Official source

Related concepts (32)

Bone

A bone is a rigid organ that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, and enable mobility. Bones come in a variety of shapes and sizes and have complex internal and external structures. They are lightweight yet strong and hard and serve multiple functions. Bone tissue (osseous tissue), which is also called bone in the uncountable sense of that word, is hard tissue, a type of specialised connective tissue.

Bone healing

Bone healing, or fracture healing, is a proliferative physiological process in which the body facilitates the repair of a bone fracture. Generally, bone fracture treatment consists of a doctor reducing (pushing) displaced bones back into place via relocation with or without anaesthetic, stabilizing their position to aid union, and then waiting for the bone's natural healing process to occur. Adequate nutrient intake has been found to significantly affect the integrity of the fracture repair.

Bone mineral

Bone mineral (also called inorganic bone phase, bone salt, or bone apatite) is the inorganic component of bone tissue. It gives bones their compressive strength. Bone mineral is formed predominantly from carbonated hydroxyapatite with lower crystallinity. Bone mineral is formed from globular and plate structures distributed among the collagen fibrils of bone and forming yet a larger structure. The bone salt and collagen fibers together constitute the extracellular matrix of bone tissue.

Bone remodeling

Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation). These processes also control the reshaping or replacement of bone following injuries like fractures but also micro-damage, which occurs during normal activity. Remodeling responds also to functional demands of the mechanical loading. In the first year of life, almost 100% of the skeleton is replaced.

Biomechanics

Biomechanics is the study of the structure, function and motion of the mechanical aspects of biological systems, at any level from whole organisms to organs, cells and cell organelles, using the methods of mechanics. Biomechanics is a branch of biophysics. In 2022, computational mechanics goes far beyond pure mechanics, and involves other physical actions: chemistry, heat and mass transfer, electric and magnetic stimuli and many others.

Related lectures (14)

Functional Anatomy: Bone Structure and Mechanical Properties

Explores bone functional anatomy, including structure, support, and protection, as well as cartilage and ligament biomechanics.

Osteoporosis Overview

Covers bone remodeling, hormone effects, menopause impact, and osteoporosis treatments.

Patient-Specific Knee Model: Patellar Strain in TKA

Explores a patient-specific knee model for evaluating patellar strain in TKA and its clinical implications.

Neuromechanics of Terrestrial Locomotion

Explores computational modeling of terrestrial locomotion, focusing on neural circuits, biomechanics, and gait optimization.

Attachment of a 2-cell