Lecture

Metabolic Diversity and Fe/Mn Cycles

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In course

ENV-202: Microbiology for engineers

"Microbiology for engineers" covers the main microbial processes that take place in the environment and in treatment systems. It presents elemental cycles that are catalyzed by microorganisms and that have a major impact on planet Earth. ...

Description

This lecture covers the metabolic diversity of organisms in terms of energy generation, focusing on oxidative and substrate-level phosphorylation. It also delves into the intricate cycles of iron (Fe) and manganese (Mn) in biological systems, detailing the processes of oxidation, reduction, and electron transfer. The mechanisms of Fe(III) reduction in microorganisms like Shewanella MR-1 are explored, highlighting the remarkable feat of exporting electrons outside the cell. Environmental examples such as acid mine drainage and ore leaching are discussed, showcasing the impact of these cycles in nature.

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Instructors (4)

Christof Holliger

Expertise BioremediationWastewater treatmentAnaerobic digestionBiogas and biofuelEnvironmental microbiologyMicrobial Ecology Teaching & PhD Past EPFL PhD Students Doulaye Koné, Katia Szynalski, Karin Kaufmann, Christian Balsiger, Julien Maillard, Enrique Lara, Benoît Zen-Ruffinen, François-Nicolas de Glutz, Laure Prat, Noam Shani, Samuel Lochmatter, David Gregory Weissbrodt, Elsa Marina Lacroix, Aamani Rupakula Boyanapalli, Géraldine Florence Buttet, Aline Sondra Adler, Mathilde Stéphanie Willemin, Lorenzo

Julien Maillard

2011 - present: Research associate at the Laboratory for Environmental Biotechnology (LBE, IIE-ENAC, EPFL) 2007 - 2010: Postdoctoral Fellow at the Laboratory for Environmental Biotechnology (LBE, IIE-ENAC, EPFL) 2005 - 2006: Postdoctoral Fellow at the University of East Anglia (UEA, Norwich, UK) 2000 - 2004: PhD thesis at the Laboratory for Environmental Biotechnology (LBE) 1995 - 2000: B.sc & M.sc at the Swiss Federal Institute for Technology, Zurich (ETHZ)

Rizlan Bernier-Latmani

HIGHER EDUCATION Summer course: Advances in Genome Technology and Bioinformatics Course at the Marine Biology Laboratory in Woods Hole, MA. October 2005. Ph.D. 2001 Civil and Environmental Engineering, Stanford University, CA (Advisor, Jim Leckie, Biodegradation of uranyl (UO22 )-complexed citrate and implications for uranyl mobility in the subsurface) M.S. 1995 Civil and Environmental Engineering, Stanford University, CA B.S. 1993 Natural Resources with Honors, Cornell University, Ithaca, NY PROFESSIONAL EMPLOYMENT 2013-present Associate professor with tenure, School of Architecture, Civil and Environmental Engineering, Swiss Federal Institute of Technology, Lausanne 2005-2013 Assistant professor tenure track, School of Architecture, Civil and Environmental Engineering, Swiss Federal Institute of Technology, Lausanne 2001-2005 Post-Graduate Researcher, Scripps Institution of Oceanography, La Jolla, CA (PI: Brad Tebo) 1995-2001 Graduate Research Assistant, Stanford University (Advisor: Jim Leckie) RESEARCH INTERESTS Gemicrobiology, metal-bacteria interactions, biological reduction and oxidation of metals, biological nanoparticle formation; Characterization of microbial communities in terrestrial environments; Using genomic, microscopic and spectroscopic tools to understand metal transformations by microorganisms. ACADEMIC HONORS Rotary Foundation University Professor grant, 2004. Swiss National Science Foundation Post-doctoral Fellowship, 2001. Leon B. Reynolds Memorial Scholarship in the School of Engineering at Stanford University, 1995-96. Graduated with Honors from Cornell University, 1993. BIBLIOMETRY http://www.researcherid.com/rid/E-4398-2011 ResearcherID: E-4398-2011

Official source

Ontological neighbourhood

Biology

Cell biology: Cell metabolism

Related concepts (32)

Phosphorylation

In biochemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology. Protein phosphorylation often activates (or deactivates) many enzymes. Phosphorylation is essential to the processes of both anaerobic and aerobic respiration, which involve the production of adenosine triphosphate (ATP), the "high-energy" exchange medium in the cell.

Adenosine diphosphate

Adenosine diphosphate (ADP), also known as adenosine pyrophosphate (APP), is an important organic compound in metabolism and is essential to the flow of energy in living cells. ADP consists of three important structural components: a sugar backbone attached to adenine and two phosphate groups bonded to the 5 carbon atom of ribose. The diphosphate group of ADP is attached to the 5’ carbon of the sugar backbone, while the adenine attaches to the 1’ carbon. ADP can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP).

Mitochondrial matrix

In the mitochondrion, the matrix is the space within the inner membrane. The word "matrix" stems from the fact that this space is viscous, compared to the relatively aqueous cytoplasm. The mitochondrial matrix contains the mitochondrial DNA, ribosomes, soluble enzymes, small organic molecules, nucleotide cofactors, and inorganic ions.[1] The enzymes in the matrix facilitate reactions responsible for the production of ATP, such as the citric acid cycle, oxidative phosphorylation, oxidation of pyruvate, and the beta oxidation of fatty acids.

Adenosine triphosphate

Adenosine triphosphate (ATP) is an organic compound that provides energy to drive and support many processes in living cells, such as muscle contraction, nerve impulse propagation, condensate dissolution, and chemical synthesis. Found in all known forms of life, ATP is often referred to as the "molecular unit of currency" of intracellular energy transfer. When consumed in metabolic processes, it converts either to adenosine diphosphate (ADP) or to adenosine monophosphate (AMP). Other processes regenerate ATP.

Microorganism

A microorganism, or microbe, is an organism of microscopic size, which may exist in its single-celled form or as a colony of cells. The possible existence of unseen microbial life was suspected from ancient times, such as in Jain scriptures from sixth century BC India. The scientific study of microorganisms began with their observation under the microscope in the 1670s by Anton van Leeuwenhoek. In the 1850s, Louis Pasteur found that microorganisms caused food spoilage, debunking the theory of spontaneous generation.

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