Lecture

Immunoengineering: Antibody Responses Modulation

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In course

BIOENG-399: Immunoengineering

Immunoengineering is an emerging field where engineering principles are grounded in immunology. This course provides students a broad overview of how engineering approaches can be utilized to study immunology, model immune systems, modulate immune response ...

Description

This lecture by the instructor covers immunoengineering strategies to modulate antibody responses, focusing on precise antibody responses and immunodominance modulation. It delves into the immune system's role in providing protection against pathogens, the design strategies to influence antibody responses, and the challenges faced in vaccine development. The lecture also discusses the concept of immunodominance, particularly in the context of influenza as a case study, and explores the use of computational tools for protein design and the development of synthetic immunogens to guide antibody maturation. Additionally, it presents innovative approaches such as reverse vaccinology and the design of multi-site cocktail vaccines to elicit specific antibody responses.

Instructor

Li Tang

Education and Training Postdoctoral Fellow, Massachusetts Institute of Technology, 2013 - 2016 Ph.D., University of Illinois at Urbana-Champaign, 2007 - 2012 B.S., Peking University, 2003-2007

Official source

Ontological neighbourhood

Health sciences

Immunology: Immune system

Infectious diseases: Topics in infectious diseases

Related concepts (32)

Humoral immunity

Humoral immunity is the aspect of immunity that is mediated by macromolecules - including secreted antibodies, complement proteins, and certain antimicrobial peptides - located in extracellular fluids. Humoral immunity is named so because it involves substances found in the humors, or body fluids. It contrasts with cell-mediated immunity. Humoral immunity is also referred to as antibody-mediated immunity. The study of the molecular and cellular components that form the immune system, including their function and interaction, is the central science of immunology.

Immune system

The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli.

Adaptive immune system

The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.

Innate immune system

The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).

Vaccine

A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified.

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Design of Immunogenic Vaccines

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Adaptive Immune Response: Steps and Activation MOOC: Introduction to immunology (part 1)