Lecture

Innate Immunity: Recognition

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In course

BIO-310: Immunology

Ce cours décrit le fonctionnement du système immunitaire humain et les bases immunologiques de la vaccination, de la transplantation, de l'immunothérapie, et de l'allergie. Il présente aussi le rôle des cellules souches dans la formation des tissus, notamm ...

Description

This lecture covers the recognition mechanisms of the innate immune system, including the recognition of pathogens through pattern recognition, direct agent recognition, and the recognition of absence or damaged tissue danger signals. It also delves into the concept of 'Modified self' and 'Microbial non-self / danger', explaining how different immune cells like NK cells, macrophages, neutrophils, mast cells, and epithelial cells play a role in innate immune recognition. Furthermore, it discusses the importance of pathogen-associated molecular patterns (PAMPs) in microbial recognition and the role of various pattern recognition receptors (PRRs) in identifying different classes of pathogens.

In MOOC

Introduction to immunology (part 1)

Instructors (2)

Bruno Lemaitre

Personal Webpage http://brunolemaitre.ch Personal Webpage http://brunolemaitre.ch Teaching & PhD PhD Students Blandine Ribotta, Yao Tian, Désirée Popelka, Prince Kumar Sah, Siqi Wang, Kenan Krakovic, Nathan Alexandre Klotz Past EPFL PhD Students Sveta Chakrabarti, Olivier Binggeli, Jeremy Keith Herren, Juan Camilo Paredes Escobar, Alfred Chng, Maroun Bou Sleiman, Jan Paul Dudzic, Mario Gonzalo Garcia Arraez, Claudia Melcarne, Alice Marra, Bianca Marie Petrignani, Mark Austin Hanson, Alexia Laurie Carboni

David Michael Suter

Teaching & PhD PhD Students Ekaterina Lyublinskaya, Yuliia Romaniuk, Joanna Agnieszka Dembska, Solomon Nshemereirwe Past EPFL PhD Students Onur Tidin, Aleksandra Mandic, Daniel Strebinger, Andrea Brigitta Alber, Mahé Raccaud, Torgil Elias Friman, Shoujie Sun, Silja Michelle Placzek, Romane Mizeret, Benjamin Martin, Sim Sakong, Stella Katharina Krämer Past EPFL PhD Students as codirector Damien Lionel Nicolas, Isabelle Chareyron, Christopher Tadhg James Wall, Kolly Dominique Courses Immunology BI

Official source

Quiz

Ontological neighbourhood

Health sciences

Immunology: Immune system

Related concepts (32)

Cell-mediated immunity

Cell-mediated immunity or cellular immunity is an immune response that does not involve antibodies. Rather, cell-mediated immunity is the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. In the late 19th century Hippocratic tradition medicine system, the immune system was imagined into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells.

Immune system

The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli.

Immune response

An immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body. In addition, there are other forms of immune response.

Adaptive immune system

The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.

White blood cell

White blood cells, also called leukocytes or leucocytes, are cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. White blood cells include three main subtypes; granulocytes, lymphocytes and monocytes. White cells is most preferred rather than the, white blood cells, because, they spend most of their time in the lymph or plasma. All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells.

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