Lecture

Immune Tissue Engineering: Mechanisms and Applications

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Description

This lecture explores the field of immune tissue engineering, focusing on the central paradigms of cell expansion, manipulation, and signaling. It delves into the processes of haematopoiesis, immune cell types, and levels of the adaptive immune response. The lecture discusses the importance of engineering immune cells and tissues for targeted immunotherapeutics, such as CAR T cells and monoclonal antibodies, in treating various diseases. It also covers the engineering of primary immune tissues like bone marrow and thymus, highlighting their significance in understanding immunological mechanisms and developing therapies. The lecture emphasizes the role of engineered materials in regulating the immune response at the cellular, tissue, and organ levels.

Official source

Ontological neighbourhood

Health sciences

Immunology: Immune system

Related concepts (32)

Adaptive immune system

The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.

Immune response

An immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body. In addition, there are other forms of immune response.

Immune system

The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli.

Cell-mediated immunity

Cell-mediated immunity or cellular immunity is an immune response that does not involve antibodies. Rather, cell-mediated immunity is the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. In the late 19th century Hippocratic tradition medicine system, the immune system was imagined into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells.

Innate immune system

The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).

Related lectures (64)

Immune System Organs and Tissues MOOC: Introduction to immunology (part 1)

Explores the primary and secondary lymphoid organs of the immune system.

An Overview of Vaccines

Covers precision tumor recognition, challenges in T cell therapy, vaccination impact, history, types, and examples of vaccines, immune response, and COVID-19 vaccine types.

Material Engineering in Cancer Immunotherapy

Covers the evasion of immune pressure by tumors, cancer immunotherapies, drug delivery strategies, and the impact of nanoparticle characteristics on tumor penetration.

Immune System Defense

Explores the immune system's defense mechanisms, including epithelial barriers, innate immunity, adaptive immunity, B and T cells, antibodies, and immunological memory.

An Overview of Vaccine: Precision Tumor Recognition by T Cells