Lecture

Natural Materials: Collagen

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In course

MSE-471: Biomaterials (pour MX)

The course introduces the main classes of biomaterials used in the biomedical field. The interactions with biological environment are discussed and challenges highlighted. State of the art examples per type of material are discussed. Students will engineer ...

Description

This lecture explores the properties and applications of collagen, a protein found in various tissues like skin, bone, and tendons. It covers the different types of collagen, its molecular changes in aging, and its use in biomaterials for tissue engineering. Additionally, it discusses elastin, elastin-like synthetic materials, cellulose, proteoglycans, and saccharides as biomaterials. The lecture also delves into the role of cellulose as a tissue engineering scaffold and the induced osteogenesis in cellulose constructs, showcasing their potential in promoting bone-like tissue growth.

Instructor

Maartje Martina Cornelia Bastings

Expertise Can we use structural material properties on the nanoscale to engineer selective interactions at the bio-interface?The goal of the Programmable Biomaterials Lab is to understand the molecular design rules behind selective multivalent interactions at the bio-interface. We use DNA as engineering tool to explore the importance of structural mechanics and precise control of valency and patterns on directional interactions and self-assembly. Expertise Can we use structural material properties on the na

Official source

Related concepts (32)

Ageing

Ageing (or aging in American English) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In a broader sense, ageing can refer to single cells within an organism which have ceased dividing, or to the population of a species. In humans, ageing represents the accumulation of changes in a human being over time and can encompass physical, psychological, and social changes.

Collagen helix

In molecular biology, the collagen triple helix or type-2 helix is the main secondary structure of various types of fibrous collagen, including type I collagen. In 1954, Ramachandran & Kartha (13, 14) advanced a structure for the collagen triple helix on the basis of fiber diffraction data. It consists of a triple helix made of the repetitious amino acid sequence glycine-X-Y, where X and Y are frequently proline or hydroxyproline. Collagen folded into a triple helix is known as tropocollagen.

Aging brain

Aging of the brain is a process of transformation of the brain in older age, including changes all individuals experience and those of illness (including unrecognised illness). Usually this refers to humans. Since life extension is only pertinent if accompanied by health span extension, and, more importantly, by preserving brain health and cognition, finding rejuvenating approaches that act simultaneously in peripheral tissues and in brain function is a key strategy for development of rejuvenating technology.

Elastic fiber

Elastic fibers (or yellow fibers) are an essential component of the extracellular matrix composed of bundles of proteins (elastin) which are produced by a number of different cell types including fibroblasts, endothelial, smooth muscle, and airway epithelial cells. These fibers are able to stretch many times their length, and snap back to their original length when relaxed without loss of energy. Elastic fibers include elastin, elaunin and oxytalan.

Osteogenesis imperfecta

Osteogenesis imperfecta (IPAˌɒstioʊˈdʒɛnəsɪs_ˌɪmpɜːrˈfɛktə; OI), colloquially known as brittle bone disease, is a group of genetic disorders that all result in bones that break easily. The range of symptoms—on the skeleton as well as on the body's other organs—may be mild to severe. Symptoms found in various types of OI include whites of the eye (sclerae) that are blue instead, short stature, loose joints, hearing loss, breathing problems and problems with the teeth (dentinogenesis imperfecta).

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