Covers the mechanisms of protein localization in cells, focusing on synthesis, sorting, and transport pathways involving the endoplasmic reticulum and Golgi apparatus.
Explores proximity-specific ribosome profiling and translational dynamics with high resolution, covering spatial regulation, cell architecture, ER's role, and advanced techniques.
Explores membrane protein quality control mechanisms at the ER, focusing on ERAD recognition, retrotranslocation, ubiquitination, and degradation of misfolded proteins.
Explores the evolution and function of protein-repair machineries, emphasizing the role of ATP-fueled unfolding machines in preventing protein aggregation and promoting proper folding.
Explores proteostasis regulation through chaperone interactions and post-translational modifications, revealing insights into protein quality control mechanisms.
Explores translation, mutations, ribosome function, protein folding, and degradation processes, emphasizing the genetic code's role in protein synthesis.
