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This lecture explores the development of environmental health strategies for personalized health, focusing on precision public health and the exposome. It delves into the challenges of recruitment, representativity, and infrastructure in large-scale health studies, emphasizing the need for sustainable and inclusive approaches. The discussion also touches on the implications of personalized health, the tension between individualization and population-level measures, and the evolving division of labor in scientific research. The lecture highlights the importance of data quality, ethical considerations, and the interdisciplinary nature of modern public health initiatives.