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Explores DNA replication mechanisms, including speed, errors, proofreading, and semiconservative nature, emphasizing the importance of maintaining DNA fidelity through mismatch repair.
Explores the complexity of cancer, challenges in research translation, and the applications of tissue engineering for cancer models and drug screening.
Covers sustaining proliferation in cancer cells, growth factors, receptor tyrosine kinases, signal transduction, viral oncogenes, and therapeutic opportunities.
Explores replicative immortality in cancer cells, focusing on telomere erosion, telomerase activity, and the role of p53 in maintaining genomic stability.
Explores the genetic basis of Prader-Villy syndrome and its comparison with Angelman syndrome, emphasizing DNA methylation patterns and chromosomal abnormalities.