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This lecture covers the use of exoskeletons in rehabilitation and mobility, focusing on the development of devices like the Lokomat, Walk Trainer, and TWIICE. It discusses the benefits of parallel kinematics, the versatility of verticalized systems, and the integration of functional electrical stimulation for gait training. The presentation also explores the biomechanical considerations behind exoskeletons, their historical origins, and the motivations driving their development. Additionally, it delves into the concept of variable impedance in locomotion and the assistance strategies employed in exoskeleton technology.