Lecture

Dynamic Connectivity in fMRI: Methods & Applications

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Description

This lecture by the instructor provides a comprehensive overview of dynamic functional connectivity methods in fMRI analysis. Starting with activation-based and static connectivity analysis, the lecture delves into the concept of non-stationary connectivity, highlighting the importance of identifying multiple brain states. The application of these methods in understanding brain disorders like schizophrenia and bipolar disorder is discussed, emphasizing the potential for distinguishing clinical groups. Various advanced techniques such as frame-wise analysis, temporal modeling, and dynamic graph analysis are explored, showcasing their utility in uncovering temporal relationships between brain states. The lecture concludes with insights on the contributions of dynamic connectivity in studying cognitive and psychiatric phenomena, cautioning about the challenges of hypothesis testing and result interpretation in this field.

Official source

Related concepts (32)

Human brain

The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head.

Brain

A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a vertebrate's body. In a human, the cerebral cortex contains approximately 14–16 billion neurons, and the estimated number of neurons in the cerebellum is 55–70 billion. Each neuron is connected by synapses to several thousand other neurons.

Bipolar disorder

Bipolar disorder, previously known as manic depression, is a mental disorder characterized by periods of depression and periods of abnormally elevated mood that each last from days to weeks. If the elevated mood is severe or associated with psychosis, it is called mania; if it is less severe, it is called hypomania. During mania, an individual behaves or feels abnormally energetic, happy or irritable, and they often make impulsive decisions with little regard for the consequences.

Outline of bipolar disorder

The following outline is provided as an overview of and topical guide to bipolar disorder: Bipolar disorder – mental disorder with cyclical periods of depression and periods of elevated mood. The elevated mood is significant and is known as mania, a severe elevation that can be accompanied by psychosis in some cases, or hypomania, a milder form of mania. During mania, an individual behaves or feels abnormally energetic, elated, or irritable. Individuals often make poorly thought out decisions with little regard to the consequences.

Gut–brain axis

The gut–brain axis is the two-way biochemical signaling that takes place between the gastrointestinal tract (GI tract) and the central nervous system (CNS). The term "gut–brain axis" is occasionally used to refer to the role of the gut microbiota in the interplay as well. The "microbiota–gut–brain (MGB or BGM) axis" explicitly includes the role of gut microbiota in the biochemical signaling events that take place between the GI tract and the CNS.

Related lectures (64)

Dynamic Functional Connectivity: Fundamentals

Covers the fundamentals of dynamic functional connectivity in the human brain, exploring challenges and analysis methods.

Neuron Classification: Types and Challenges

Explores neuron classification, highlighting the importance of understanding brain complexity and the challenges in defining cell types.

Connectivity-Informed Brain Activity Interpretation

Explores integrating brain connectivity to decode and interpret brain activity using graph signal processing and spectral residual networks.

Spinal Cord fMRI at 7 Tesla

Explores advancements in spinal cord fMRI at 7 Tesla, highlighting its significance in understanding central nervous system pathologies.

Neuroprosthetics: Advances in fMRI in Rodents