Lecture

Neuroprosthetics: Advances in fMRI in Rodents

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Description

This lecture explores new advances in functional Magnetic Resonance Imaging (fMRI) in rodents, focusing on the transition from network psychology to network physiology. Dr. Valerio Zerbi discusses the Center for Neuroprosthetics' research on the brain's connectivity and the impact of activating the Locus Coeruleus/Norepinephrine system. The presentation covers the infrastructure, core members, and core activities of the Center for Biomedical Imaging. It delves into the study design involving chemogenetics and optogenetics, as well as the implications of activating the Locus Coeruleus on brain network dynamics. The lecture concludes with insights into awake fMRI in rodents and the potential of rodent fMRI in understanding brain networks and their physiological drivers.

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Related concepts (32)

Large-scale brain network

Large-scale brain networks (also known as intrinsic brain networks) are collections of widespread brain regions showing functional connectivity by statistical analysis of the fMRI BOLD signal or other recording methods such as EEG, PET and MEG. An emerging paradigm in neuroscience is that cognitive tasks are performed not by individual brain regions working in isolation but by networks consisting of several discrete brain regions that are said to be "functionally connected".

Functional neuroimaging

Functional neuroimaging is the use of neuroimaging technology to measure an aspect of brain function, often with a view to understanding the relationship between activity in certain brain areas and specific mental functions. It is primarily used as a research tool in cognitive neuroscience, cognitive psychology, neuropsychology, and social neuroscience.

Brain simulation

Brain simulation is the concept of creating a functioning computer model of a brain or part of a brain. Brain simulation projects intend to contribute to a complete understanding of the brain, and eventually also assist the process of treating and diagnosing brain diseases. Various simulations from around the world have been fully or partially released as open source software, such as C. elegans, and the Blue Brain Project Showcase.

Functional magnetic resonance imaging

Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases. The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa in 1990.

Brain

A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a vertebrate's body. In a human, the cerebral cortex contains approximately 14–16 billion neurons, and the estimated number of neurons in the cerebellum is 55–70 billion. Each neuron is connected by synapses to several thousand other neurons.

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