Lecture

Activation and Differentiation of T Cells

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

In course

BIO-479: Immunology - advances and therapeutic implications

The students acquire advanced level knowledge regarding the functioning of the (vertebrate) immune system. A strong focus is placed on the molecular mechanisms underlying innate and adaptive immune responses and their implications for medicine. ...

Description

This lecture covers the activation and differentiation of T lymphocytes, focusing on the process of naive T cells recognizing antigens, receiving activating stimuli, and differentiating into effector and memory cells. It explains the sequence of events in T cell responses, the signals required for T lymphocyte activation, and the role of costimulatory molecules. The lecture also discusses the functions of CD4+ and CD8+ effector T cells, the regulation of IL-2 receptor, and the therapeutic implications of costimulatory blockade. Additionally, it explores the properties and functions of memory T cells, the differentiation and functions of CD4+ effector T cells, and the major subsets of helper T cells.

This video is available exclusively on Mediaspace for a restricted audience. Please log in to MediaSpace to access it if you have the necessary permissions.

Watch on Mediaspace

Official source

Ontological neighbourhood

Health sciences

Immunology: Immune system

Related concepts (32)

T helper cell

The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. They aid the activity of other immune cells by releasing cytokines. They are considered essential in B cell antibody class switching, breaking cross-tolerance in dendritic cells, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages and neutrophils.

Immune response

An immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body. In addition, there are other forms of immune response.

Immune system

The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli.

Adaptive immune system

The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.

Antigen-presenting cell

An antigen-presenting cell (APC) or accessory cell is a cell that displays antigen bound by major histocompatibility complex (MHC) proteins on its surface; this process is known as antigen presentation. T cells may recognize these complexes using their T cell receptors (TCRs). APCs process antigens and present them to T-cells. Almost all cell types can present antigens in some way. They are found in a variety of tissue types.

Related lectures (64)

Adaptive Immune Response: Steps and Activation MOOC: Introduction to immunology (part 1)

Explores the steps and phases of the adaptive immune response.

Immunometabolism: Basic Concepts and Translational Opportunities

Explores the basic concepts and translational opportunities in immunometabolism, emphasizing the intricate interactions between immune cells and different cell types.

Immune Engineering: Cancer Immunotherapy Strategies

Explores cancer immunotherapy strategies, including blocking inhibitory pathways, increasing effector T cells, and enhancing cancer vaccines.

Immune Tissue Engineering: Mechanisms and Applications

Explores immune tissue engineering, focusing on cell manipulation, immune cell types, and adaptive immune response levels, highlighting the importance of engineering immune cells for targeted therapies.

Fundamental Immunology: Introduction Teaser MOOC: Introduction to immunology (part 1)