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This lecture explores the concept of Circular Economy, focusing on Closed-Loop Lifecycle Management, Degradation and Failure in industrial processes, and the implementation of Zero Defect Manufacturing. It delves into setting up closed loops in the technical sphere, defect prevention, and the use of Zero Defect Manufacturing to reduce costs and improve product quality. The lecture also covers the importance of data sharing for manufacturing, the role of Big Data Analytics, and the development of Intelligent Autonomous Products. Additionally, it discusses the significance of Ontologies and Big Data in industrial processes, emphasizing the need for Semantics-Driven Architecture and Predictive Maintenance for Zero Defect Manufacturing.